Phenotypes associated with this allele

• Allele Symbol: Rxra^tm1Ipc
• Allele Name: targeted mutation 1, Pierre Chambon
• Allele ID: MGI:1857511
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxra^tm1Ipc/Rxra^tm1Ipc	involves: 129S2/SvPas	MGI:3629417
ht2	Rxra^tm1Ipc/Rxra^tm2Ipc	involves: 129S2/SvPas * C57BL/6	MGI:3839232
cn3	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622670
cn4	Rxra^tm1Ipc/Rxra^tm1Ipc Tg(Myh6-Rxra)41Pcn/0	involves: 129S2/SvPas	MGI:5906923
cn5	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629408
cx6	Rxra^tm1Ipc/Rxra^tm1Ipc Rxrb^tm1Mma/Rxrb^tm1Mma	involves: 129S2/SvPas * C57BL/6	MGI:3839233

Genotype
MGI:3629417

hm1

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:60351 )

• no fetuses are recovered after E16.5

cardiovascular system

ventricular hypoplasia ( J:60351 )

• ventricular myocardial hypoplasia at E14.5

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Genotype
MGI:3839232

ht2

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm2Ipc
• Genetic Background: involves: 129S2/SvPas * C57BL/6

vision/eye

abnormal eye development ( J:146761 )

• 1of 4 mice displayed a characteristic Rxra null phenotype

• 3 of 4 mice displayed a bilateral persistent and hyperplasic primary vitreous body

Genotype
MGI:3622670

cn3

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc; Rxrb^tm1Mma/Rxrb^tm1Pcn; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: 129S2/SvPas

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

immune system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

integument

alopecia ( J:102470 )

• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5

hair follicle degeneration ( J:102470 )

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

dermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia

mixed cellular infiltration to dermis ( J:102470 )

• mutants show a weaker infiltration of the dermis

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

epidermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis

hematopoietic system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

Genotype
MGI:5906923

cn4

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc; Tg(Myh6-Rxra)41Pcn/0
• Genetic Background: involves: 129S2/SvPas

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:60351 )

• no fetuses are recovered after E16.5

cardiovascular system

ventricular hypoplasia ( J:60351 )

• ventricular myocardial hypoplasia at E14.5

Genotype
MGI:3629408

cn5

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm4Ipc; Rxrb^tm1Mma/Rxrb^tm1Pcn; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Genotype
MGI:3839233

cx6

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc; Rxrb^tm1Mma/Rxrb^tm1Mma
• Genetic Background: involves: 129S2/SvPas * C57BL/6

vision/eye

abnormal cornea stroma morphology ( J:146761 )

• the ventral portion is thickened at E14.5

ventral rotation of lens ( J:146761 )

• ventral rotation is seen at E14.5

abnormal eye development ( J:146761 )

• at E14.5 all mice have a persistent and hyperplasic primary vitreous body

abnormal eyelid morphology ( J:146761 )

• closer eyelid folds in mice at E14.5

abnormal ocular fundus morphology ( J:146761 )

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

abnormal retina morphology ( J:146761 )

• shortened ventral retina at E14.5

cardiovascular system

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice

abnormal conotruncus septation ( J:146761 )

• agenesis of the conotruncal septum is occasionally seen at E14.5

nervous system

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

muscle

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice