Phenotypes associated with this allele

• Allele Symbol: Tlx2^tm1Ut
• Allele Name: targeted mutation 1, University of Toronto
• Allele ID: MGI:1857514
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlx2^tm1Ut/Tlx2^tm1Ut	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2177679

Genotype
MGI:2177679

hm1

• Allelic Composition: Tlx2^tm1Ut/Tlx2^tm1Ut
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:48372 )

• embryos die at E7.0 - E7.5

embryo

abnormal ectoderm development ( J:48372 )

• ectoderm of primitive streak disorganized and consisting of a multicellular layer

abnormal embryonic tissue morphology ( J:48372 )

abnormal primitive streak formation ( J:48372 )

• primitive streak deformed; undulating, non-uniform, with little mesoderm evident

abnormal extraembryonic tissue morphology ( J:48372 )

abnormal amnion morphology ( J:48372 )

• posterior amniotic fold underdeveloped