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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Agtpbp1pcd-3J
Purkinje cell degeneration 3 Jackson
MGI:1857523
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Agtpbp1pcd-3J/Agtpbp1pcd-3J BALB/cByJ-Agtpbp1pcd-3J/J MGI:5897862
hm2
Agtpbp1pcd-3J/Agtpbp1pcd-3J involves: BALB/cByJ MGI:2175211


Genotype
MGI:5897862
hm1
Allelic
Composition
Agtpbp1pcd-3J/Agtpbp1pcd-3J
Genetic
Background
BALB/cByJ-Agtpbp1pcd-3J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtpbp1pcd-3J mutation (2 available); any Agtpbp1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal red blood cell, white blood cells and platelet counts, platelet morphology and spleen size

behavior/neurological
N
• no obvious phenotypes in neural degeneration or motor skill disorders

homeostasis/metabolism
N
• mice exhibit normal bleeding time




Genotype
MGI:2175211
hm2
Allelic
Composition
Agtpbp1pcd-3J/Agtpbp1pcd-3J
Genetic
Background
involves: BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtpbp1pcd-3J mutation (2 available); any Agtpbp1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• age of onset 3 - 4 weeks

cellular
• abnormally shaped sperm

immune system
N
• mice exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection

reproductive system
• abnormally shaped sperm

vision/eye
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete degeneration over the course of 1 year

nervous system
• thalamic neuronal degeneration, age of onset 50 - 60 days
• mitral cells of olfactory bulb degenerate slowly and progressivley
• partial granule cell degeneration following Purkinje cell degeneration
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete degeneration over the course of 1 year





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory