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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agtpbp1pcd-3J
Purkinje cell degeneration 3 Jackson
MGI:1857523
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Agtpbp1pcd-3J/Agtpbp1pcd-3J BALB/cByJ-Agtpbp1pcd-3J/J MGI:5897862
hm2
 		Agtpbp1pcd-3J/Agtpbp1pcd-3J involves: BALB/cByJ MGI:2175211


Genotype
MGI:5897862
hm1
Allelic
Composition		 Agtpbp1pcd-3J/Agtpbp1pcd-3J
Genetic
Background		 BALB/cByJ-Agtpbp1pcd-3J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtpbp1pcd-3J mutation (2 available); any Agtpbp1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:233744 )
N
• mice exhibit normal red blood cell, white blood cells and platelet counts, platelet morphology and spleen size

behavior/neurological
behavior/neurological phenotype ( J:233744 )
N
• no obvious phenotypes in neural degeneration or motor skill disorders

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:233744 )
N
• mice exhibit normal bleeding time




Genotype
MGI:2175211
hm2
Allelic
Composition		 Agtpbp1pcd-3J/Agtpbp1pcd-3J
Genetic
Background		 involves: BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtpbp1pcd-3J mutation (2 available); any Agtpbp1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:74929 )
• age of onset 3 - 4 weeks

cellular
abnormal male germ cell morphology ( J:74929 )
• abnormally shaped sperm

immune system
immune system phenotype ( J:231311 )
N
• mice exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection

reproductive system
abnormal male germ cell morphology ( J:74929 )
• abnormally shaped sperm

vision/eye
retina photoreceptor degeneration ( J:74929 )
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete degeneration over the course of 1 year

nervous system
abnormal thalamus morphology ( J:74929 )
• thalamic neuronal degeneration, age of onset 50 - 60 days
abnormal mitral cell morphology ( J:74929 )
• mitral cells of olfactory bulb degenerate slowly and progressivley
abnormal cerebellar granule layer morphology ( J:74929 )
• partial granule cell degeneration following Purkinje cell degeneration
retina photoreceptor degeneration ( J:74929 )
• photoreceptor cell degeneration, age of onset, 18 - 25 days
• complete degeneration over the course of 1 year




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory