Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ngftm1Gne targeted mutation 1, Genentech MGI:1857535 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite defects in the dorsal root ganglion, mice exhibit normal peroneal nerves
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• at E14.5, small diameter neurons in the dorsal root ganglion are eliminated unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mutants die within the first 3 days of birth and others are able to ingest some food and survive 1-4 weeks
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• some mutants surviving the first week develop a tremor, that is most evident during locomotion
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• some mutants surviving the first week show mild gait abnormalities
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• unresponsive to tactile stimuli, decrease pain responsiveness in tail flick test, absent pain responsiveness in tail pinch test
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• smaller at birth
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• weights range from 75-95% of the mean weights of controls mutants fail to gain weight
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• homozygotes that survive the first days of life gain weight more slowly and are developmentally delayed
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• delayed opening, blepharoptosis (droopy eyelid)
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• all mutants surviving until eye opening display ptosis
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• by P14, superior cervical ganglia are not visible
• however, the nodose ganglia are normal
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• superior cervical ganglia are smaller at early postnatal times
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• absence of primary sensory afferents in the dorsal horn of spinal cord
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• absence of primary sensory afferents in the dermis and epidermis
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• dorsal root ganglia at P3 contain fewer neuronal profiles; neuronal cell counts from the fourth and fifth lumbar (L4 and L5) ganglia show a 70% reduction
• lumbar or cervical dorsal root ganglia show a complete absence of small cells in the ganglia but no evidence of cell loss in the large range
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• delayed hair growth
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• absence of primary sensory afferents in the dermis and epidermis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit impaired object recognition memory
• however, exploratory behavior is unaffected
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• mice exhibit delayed learning in the Morris water maze
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• density of ChAT+ neurons in the medial septum and striatum are decreased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants display a small but significant prolongation in tail flick test
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• mutants display a decrease in cell number in the dorsal root ganglia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5, extension of hind limb nerves is defective compared to in wild-type mice
• extension of the third digital branch of the deep peroneal nerve is reduced 27% compared to in wild-type mice
• extension of the lateral plantar nerve is reduced 13% compared to in wild-type mice
• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice
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• mice exhibit excessive nociceptor axons in deep spinal cord layers compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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