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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map2k4tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:1857536
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map2k4tm1Pngr/Map2k4tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:2167066


Genotype
MGI:2167066
hm1
Allelic
Composition		 Map2k4tm1Pngr/Map2k4tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Pngr mutation (1 available); any Map2k4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:51597 )
• embryos die between E10.5 and E12.5

hematopoietic system
anemia ( J:51597 )
• severe by E11.5
• normal vasculogenesis
• normal hematopoiesis

liver/biliary system
abnormal liver development ( J:51597 )
• primordial liver forms, but is severely disorganized and contained clusters of hematopoietic precursor and erythrocyte cells; becomes apoptotic




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory