Analysis Tools
nervous system
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• 1 year old C57BL/Ola mice showed faster Wallerian degeneration than 4 week old mice, with compund action potentials recorded in a distal nerve stump 5 days after section in 4 week old mutant mice, but not 1 year old mutant mice
(J:3359)
• following optic nerve transection, the axons of retinal ganglion cells undergo very slow Wallerian degeneration
(J:19950)
• 5 days after severing the sciatic nerve, mice show slow Wallerian degeneration evidenced by an intact cytoskeleton and plasma membrane, while control mice show a destruction of cytoarchitecture in the distal portion of the severed nerve
(J:19951)
• in addition, the distal portions of mutant severed nerves show an ability to conduct action potentials up to 14 days post section, while control nerves stop conducting 2 days after the nerve is cut
(J:19951)
• invasion by polymorphs and macrophages of the distal portion of the severed nerve is not observed in mutant mice, resulting in an absence of myelin breakdown; controls show an increase in myeloperoxidase positive cells and Schwann cell proliferation within 3 days of section
(J:19951)
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• while retinal ganglion cells undergo retrograde degeneration in response to optic nerve injury, they do so at a much slower rate than in other strains
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• the rate of regeneration and recovery of function after sciatic nerve crush is incomplete compared to C57BL/6J mice, as determined by sciatic functional index (SFI) using measurements of walking ability and by measurements of axonal transport
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• the rate of regeneration and recovery of function after sciatic nerve crush is delayed compared to C57BL/6J mice, as determined by SFI using measurments of walking ability and by measurements of axonal transport
(J:12834)
• the rate of regeneration and recovery of function after facial nerve crush is delayed compared to C57BL/6J mice, as observed by vibrissae movement
(J:12834)
• the rate of regeneration and recovery of motor function in the soleus muscle after a crush of the sciatic nerve is similar in mutant mice and controls, with a slight delay in recovery of normal conduction velocity in mutant mice
(J:19951)
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vision/eye
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• while retinal ganglion cells undergo retrograde degeneration in response to optic nerve injury, they do so at a much slower rate than in other strains
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homeostasis/metabolism
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• 1 year old C57BL/Ola mice showed faster Wallerian degeneration than 4 week old mice, with compund action potentials recorded in a distal nerve stump 5 days after section in 4 week old mutant mice, but not 1 year old mutant mice
(J:3359)
• following optic nerve transection, the axons of retinal ganglion cells undergo very slow Wallerian degeneration
(J:19950)
• 5 days after severing the sciatic nerve, mice show slow Wallerian degeneration evidenced by an intact cytoskeleton and plasma membrane, while control mice show a destruction of cytoarchitecture in the distal portion of the severed nerve
(J:19951)
• in addition, the distal portions of mutant severed nerves show an ability to conduct action potentials up to 14 days post section, while control nerves stop conducting 2 days after the nerve is cut
(J:19951)
• invasion by polymorphs and macrophages of the distal portion of the severed nerve is not observed in mutant mice, resulting in an absence of myelin breakdown; controls show an increase in myeloperoxidase positive cells and Schwann cell proliferation within 3 days of section
(J:19951)
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