Phenotypes associated with this allele

• Allele Symbol: Axin1^Fu-Tg1
• Allele Name: fused transgenic 1
• Allele ID: MGI:1857546
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Axin1^Fu-Tg1/Axin1^Fu-Tg1	involves: C57BL/6J * CBA/J	MGI:3654112
ht2	Axin1^Fu-Tg1/Axin1^tm1(Axin2)Cos	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N	MGI:3582069
ht3	Axin1^Fu-ki/Axin1^Fu-Tg1	involves: BTBR * C57BL/6J * CBA/J	MGI:3663641

Genotype
MGI:3654112

hm1

• Allelic Composition: Axin1^Fu-Tg1/Axin1^Fu-Tg1
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:28303 )

• lethality around E9 to E10

growth/size/body

shortened head ( J:147293 )

• truncated head at E9.5

embryonic growth retardation ( J:28303 , J:147293 )

• most mutants at E8.5 appear retarded in development, resembling E8 embryos (J:28303)

• developmental delay at E9.5 (J:147293)

decreased embryo size ( J:147293 )

embryo

rostral-caudal axis duplication ( J:28303 )

• exhibit duplication of the embryonic axis and parts of the embryo

embryonic growth retardation ( J:28303 , J:147293 )

• most mutants at E8.5 appear retarded in development, resembling E8 embryos (J:28303)

• developmental delay at E9.5 (J:147293)

decreased embryo size ( J:147293 )

abnormal embryonic tissue morphology ( J:28303 )

• the posterior end of the primary embryo protrudes through the visceral yolk sac in to the yolk cavity

• some embryos have extra structures near the head folds, often protruding through the yolk sac and in other cases, the head folds appear to protrude through the yolk sac

abnormal axial mesoderm morphology ( J:41619 )

• E8.5 embryos exhibit duplication of anterior axial mesoderm

incomplete rostral neuropore closure ( J:28303 , J:147293 )

• by E9.5, the head folds usually failed to close (J:28303)

• open head folds (J:147293)

kinked neural tube ( J:28303 )

abnormal allantois morphology ( J:28303 )

• some exhibit two allantoises connected to the placenta

abnormal amniotic cavity morphology ( J:28303 )

• abnormal accumulation of cellular debris in the amniotic cavity

cardiovascular system

cardia bifida ( J:28303 , J:147293 )

• seen in severely affected mutants (J:28303)

enlarged pericardium ( J:28303 , J:147293 )

• heart appears normal in most cases, however occasionally the pericardium is abnormally expanded (J:28303)

nervous system

incomplete rostral neuropore closure ( J:28303 , J:147293 )

• by E9.5, the head folds usually failed to close (J:28303)

• open head folds (J:147293)

kinked neural tube ( J:28303 )

forebrain hypoplasia ( J:28303 )

• forebrain is absent or severely underdeveloped by E9.5

absent forebrain ( J:28303 )

• forebrain is absent or severely underdeveloped by E9.5

craniofacial

shortened head ( J:147293 )

• truncated head at E9.5

Genotype
MGI:3582069

ht2

• Allelic Composition: Axin1^Fu-Tg1/Axin1^{tm1(Axin2)Cos}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

normal phenotype

no abnormal phenotype detected ( J:98893 )

• mice homozygous for a null mutation were fertile and had normal life span; no premature deaths, obvious behavioral defects or overt tumors are found

Genotype
MGI:3663641

ht3

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-Tg1
• Genetic Background: involves: BTBR * C57BL/6J * CBA/J

cardiovascular system

enlarged pericardium ( J:28303 )

• expanded pericardium

embryo

embryonic growth retardation ( J:28303 )

• seen at E9.5

abnormal cephalic neural fold morphology ( J:28303 )

• E9.5 embryos exhibit poorly formed head folds and/or large globular mass attached to the head folds

abnormal allantois morphology ( J:28303 )

growth/size/body

flat head ( J:28303 )

• E9.5 embryos exhibit a flattened head

embryonic growth retardation ( J:28303 )

• seen at E9.5

craniofacial

flat head ( J:28303 )

• E9.5 embryos exhibit a flattened head