Phenotypes associated with this allele

• Allele Symbol: Tal1^tm1Wehi
• Allele Name: targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• Allele ID: MGI:1857566
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tal1^tm1Wehi/Tal1^tm1Wehi	involves: 129S1/Sv * C57BL/6	MGI:2174753

Genotype
MGI:2174753

hm1

• Allelic Composition: Tal1^tm1Wehi/Tal1^tm1Wehi
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Appearance and histology of Tal1^tm1Wehi/Tal1^tm1Wehi embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:27458 )

• homozygotes die by E10.5; only resorption sites with small embryonic remnants are detected at E11.5

embryo

absent vitelline blood vessels ( J:27458 )

• at E8.75-E9.0, mutant yolk sacs show absence of major vitelline vessels

incomplete embryo turning ( J:27458 )

• ~1/3 of homozygotes fail to complete axial rotation

embryonic growth arrest ( J:27458 )

• only a few mutant embryos develop beyond 18 somites (range 8-20)

embryonic growth retardation ( J:27458 )

• homozygotes become increasingly retarded after E8.75

absent visceral yolk sac blood islands ( J:27458 )

• at E8.75-E9.0, mutant yolk sacs show absence of blood islands

pale yolk sac ( J:27458 )

• by E8.75-E9.0, mutant yolk sacs are significantly pale

abnormal embryonic hematopoiesis ( J:27458 )

• homozygotes exhibit failure of yolk sac hematopoiesis, with no erythrocytes found in embryonic vessels

• in vitro, cultures of E8.5-E9.5 mutant yolk sacs display absence of all hematopoietic colony types

cardiovascular system

absent vitelline blood vessels ( J:27458 )

• at E8.75-E9.0, mutant yolk sacs show absence of major vitelline vessels

distended pericardium ( J:27458 )

• at E8.75-E9.0, mutant embryos exhibit dilated pericardial sacs but normal cardiac contraction

homeostasis/metabolism

skin edema ( J:27458 )

• by E8.75-E9.0, mutant embryos are edematous

growth/size/body

embryonic growth retardation ( J:27458 )

• homozygotes become increasingly retarded after E8.75

hematopoietic system

abnormal embryonic hematopoiesis ( J:27458 )

• homozygotes exhibit failure of yolk sac hematopoiesis, with no erythrocytes found in embryonic vessels

• in vitro, cultures of E8.5-E9.5 mutant yolk sacs display absence of all hematopoietic colony types

integument

skin edema ( J:27458 )

• by E8.75-E9.0, mutant embryos are edematous

pallor ( J:27458 )