All Phenotypes Runx1<tm1Spe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Runx1^tm1Spe
targeted mutation 1, Nancy A Speck
MGI:1857568

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Runx1^tm1Spe/Runx1^tm1Spe	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2167339
ht2	Runx1^tm1Spe/Runx1⁺	either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/Ca) or (involves: 129S4/SvJae * C57BL/6 * CBA/Ca)	MGI:2655966
ht3	Runx1^tm1Spe/Runx1⁺	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:3709771
ht4	Runx1^tm1Spe/Runx1^tm2Spe	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2671954
ht5	Runx1^tm1Spe/Runx1^tm3Itan	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4458935
ht6	Runx1^tm1Spe/Runx1^tm1Yg	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:4459011

Allelic Composition	Runx1^tm1Spe/Runx1^tm1Spe
Genetic Background	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gross and microscopic views of pathologic lesions in Runx1^tm1Spe/Runx1^tm1Spe mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:35115 )

• die between E11.5 and E12.5

cardiovascular system

hemorrhage ( J:35115 )

• extensive hemorrhages, with 14% of homozygotes showing hemorrhaging at E10.5, 73% at E11.5 and 100% at E12.5

internal hemorrhage ( J:35115 )

• most extensive hemorrhages involve the central nervous system and are located in the isthmus, ventral metencephalon, and spinal cord

• focal petechial hemorrhages are seen in peripheral nerves and intersegmental regions, especially prominent at the nerve roots of VII-VIII cranial nerve complex and at some spinal nerves

• mesodermal petechial hemorrhages are seen in a small number of embryos

hemopericardium ( J:35115 )

• pericardiac and peritoneal hemorrhages are seen in some embryos

hematopoietic system

abnormal erythropoiesis ( J:35115 )

• only primitive nucleated erythroid cells are seen in liver sections or smears at E11 and E12.5, respectively, indicating a block in definitive erythropoiesis

• no erythroid colonies differentiate from yolk sac cells as in wild-type

impaired myelopoiesis ( J:35115 )

• no myeloid colonies differentiate from yolk sac cells as in wild-type

impaired hematopoiesis ( J:35115 )

• fetal liver hematopoiesis is impaired, however primitive erythrocytes are normal

increased nucleated erythrocyte cell number ( J:35115 )

• only primitive nucleated erythroid cells are seen in liver sections or smears at E11 and E12.5, respectively, indicating a block in definitive erythropoiesis

immune system

impaired myelopoiesis ( J:35115 )

• no myeloid colonies differentiate from yolk sac cells as in wild-type

homeostasis/metabolism

hemopericardium ( J:35115 )

• pericardiac and peritoneal hemorrhages are seen in some embryos

embryo

embryo tissue necrosis ( J:35115 )

• foci of cellular necrosis, often bilateral and symmetrical, are seen at the nerve/CNS interfaces of cranial and spinal nerves at E10.5

• somitic/intersomitic necrosis is seen in the lower thoracic and lumbar regions

Allelic Composition	Runx1^tm1Spe/Runx1⁺
Genetic Background	either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/Ca) or (involves: 129S4/SvJae * C57BL/6 * CBA/Ca)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:80829 )

• survival of mutants shows slight but significant increase compared to transgenic mice on a wild-type Runx1 background

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:80829 )

• survival of mutants shows slight but significant increase compared to transgenic mice on a wild-type Runx1 background

immune system

increased T cell derived lymphoma incidence ( J:80829 )

• survival of mutants shows slight but significant increase compared to transgenic mice on a wild-type Runx1 background

hematopoietic system

increased T cell derived lymphoma incidence ( J:80829 )

• survival of mutants shows slight but significant increase compared to transgenic mice on a wild-type Runx1 background

Allelic Composition	Runx1^tm1Spe/Runx1⁺
Genetic Background	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:80829 )

N	• mice infected with Moloney murine leukemia virus within 24 hours of birth do not show any increase in tumor incidence or latency compared to infected littermate controls

embryo

abnormal embryonic hematopoiesis ( J:120100 )

• at E11.5, animals have a >3-fold decrease in CFU-C in AGM (aorta/gonad/mesonephros) regions than wild-type embryos in the AGM region

hematopoietic system

abnormal embryonic hematopoiesis ( J:120100 )

• at E11.5, animals have a >3-fold decrease in CFU-C in AGM (aorta/gonad/mesonephros) regions than wild-type embryos in the AGM region

decreased CD4-positive, alpha-beta T cell number ( J:120100 )

• a significant decrease in percentage of CD4+ splenic T cells and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed

immune system

decreased CD4-positive, alpha-beta T cell number ( J:120100 )

• a significant decrease in percentage of CD4+ splenic T cells and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed

Allelic Composition	Runx1^tm1Spe/Runx1^tm2Spe
Genetic Background	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)
Runx1^tm2Spe mutation (0 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal embryonic hematopoiesis ( J:56184 )

• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries

• no fetal liver hematopoiesis

• no yolk sac hematopoiesis

embryo

abnormal embryonic hematopoiesis ( J:56184 )

• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries

• no fetal liver hematopoiesis

• no yolk sac hematopoiesis

Allelic Composition	Runx1^tm1Spe/Runx1^tm3Itan
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)
Runx1^tm3Itan mutation (0 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:160791 )

N	• unlike Runx1^tm1Spe homozygotes, mice do not exhibit embryonic lethality

hematopoietic system

hematopoietic system phenotype ( J:160791 )

N	• unlike Runx1^tm1Spe homozygotes, mice do not exhibit fetal liver anemia

Allelic Composition	Runx1^tm1Spe/Runx1^tm1Yg
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Spe mutation (1 available); any Runx1 mutation (34 available)
Runx1^tm1Yg mutation (2 available); any Runx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:160791 )

hematopoietic system

anemia ( J:160791 )

• severe in the fetal liver at E12.5

cardiovascular system

internal hemorrhage ( J:160791 )

• in the central nervous system at E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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