renal/urinary system
• glomerular volume is increased 2-fold relative to controls at 3 months of age and 3-fold at 5 months of age but the glomerulosclerosis found on the ROP background is absent with only a minimal increase in extracellular matrix at 5 months of age
• the mean cell number per glomerulus is increased 21% relative to controls and the glomerular labeling index is increased 2.6 fold at 3 and 5 months of age
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• only a minimal increase in extracellular matrix is noted at 5 months of age
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• mean glomerular number per kidney is reduced by 50% at 3 months of age
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• 34% reduction in kidney weight compared with controls at 3 months of age
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