Phenotypes associated with this allele

• Allele Symbol: Epor^tm1Cos
• Allele Name: targeted mutation 1, Frank Costantini
• Allele ID: MGI:1857575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epor^tm1Cos/Epor^tm1Cos	involves: 129S/SvEv * C57BL/6J	MGI:2167384

Genotype
MGI:2167384

hm1

• Allelic Composition: Epor^tm1Cos/Epor^tm1Cos
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:31156 )

• lethality by E13.5

hematopoietic system

anemia ( J:31156 )

• embryos become increasingly anemic between E10.5 and E12.5

abnormal erythrocyte morphology ( J:31156 )

• most of the erythoroid cells at E12.5 are apoptotic

abnormal erythropoiesis ( J:31156 )

• in the fetal liver, definitive erythropoiesis beyond the late progenitor stage is inhibited and virtually no definitive erythrocytes are produced

• however, in the few definitive erythroblasts that are formed, early stages of differentiation do occur

decreased erythrocyte cell number ( J:31156 )

• virtually no definitive erythrocytes are produced

abnormal embryonic erythrocyte morphology ( J:31156 )

• formation of primitive erythrocytes in the early yolk sac, their differentiation between E9.5 and E12.5, and their release into the circulation appears to occur normally, however, they are reduced in size, and by E10.5 primitive blood cell numbers fall to 14% of normal and 10% of normal by E12.5, indicating that proliferation after E9.5 is impaired

liver/biliary system

small liver ( J:31156 )

• liver is small at E12.5

pale liver ( J:31156 )

• liver is pale at E12.5