All Phenotypes Gata1<tm1Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^tm1Sho
targeted mutation 1, Stuart Orkin
MGI:1857600

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gata1^tm1Sho/Gata1⁺	involves: 129S4/SvJae * C57BL/6	MGI:2177552
cx2	Gata1^tm1Sho/Y Tg(Gata1*)#Mym/0	involves: 129S4/SvJae * C57BL/6 * DBA/2J	MGI:4450924
cx3	Gata1^tm1Sho/Gata1^tm1Sho Tg(Gata1*)#Mym/0	involves: 129S4/SvJae * C57BL/6 * DBA/2J	MGI:4450925
cx4	Gata1^tm1Sho/Y Tg(Gata1)#Mym/0	involves: 129S4/SvJae * C57BL/6 * DBA/2J	MGI:4450926
cx5	Gata1^tm1Sho/Gata1^tm1Sho Tg(Gata1)#Mym/0	involves: 129S4/SvJae * C57BL/6 * DBA/2J	MGI:4450927
ot6	Gata1^tm1Sho/Y	involves: 129S4/SvJae * C57BL/6	MGI:2177553

Allelic Composition	Gata1^tm1Sho/Gata1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:36249 )

• anemia is present at birth and during the neonatal period, then decreases as the mice age

decreased eosinophil cell number ( J:88711 )

• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils

immune system

decreased eosinophil cell number ( J:88711 )

• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils

Allelic Composition	Gata1^tm1Sho/Y Tg(Gata1*)#Mym/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)
Tg(Gata1*)#Mym mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased megakaryocyte cell number ( J:158252 )

• at P5

abnormal megakaryocyte progenitor cell morphology ( J:158252 )

• increased

decreased erythrocyte cell number ( J:158252 )

• at P0

decreased hematocrit ( J:158252 )

• at P0

decreased hemoglobin content ( J:158252 )

• at P0

thrombocytosis ( J:158252 )

• at P0

increased leukocyte cell number ( J:158252 )

• at P0

immune system

increased leukocyte cell number ( J:158252 )

• at P0

Allelic Composition	Gata1^tm1Sho/Gata1^tm1Sho Tg(Gata1*)#Mym/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)
Tg(Gata1*)#Mym mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased megakaryocyte cell number ( J:158252 )

• at P5

abnormal megakaryocyte progenitor cell morphology ( J:158252 )

• increased

decreased erythrocyte cell number ( J:158252 )

• at P0

decreased hematocrit ( J:158252 )

• at P0

decreased hemoglobin content ( J:158252 )

• at P0

thrombocytosis ( J:158252 )

• at P0

increased leukocyte cell number ( J:158252 )

• at P0

immune system

increased leukocyte cell number ( J:158252 )

• at P0

Allelic Composition	Gata1^tm1Sho/Y Tg(Gata1)#Mym/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)
Tg(Gata1)#Mym mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:158252 )

N	• mice exhibit normal numbers of megakaryocytes at P5

Allelic Composition	Gata1^tm1Sho/Gata1^tm1Sho Tg(Gata1)#Mym/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)
Tg(Gata1)#Mym mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:158252 )

N	• mice exhibit normal numbers of megakaryocytes at P5

Allelic Composition	Gata1^tm1Sho/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:36249 )

• male mice die between E10.5 and E11.5 due to severe anemia

hematopoietic system

abnormal erythropoiesis ( J:36249 )

• embryonic red blood cells are arrested at the proerythroblast stage and display occasional nuclear fragmentation

anemia ( J:36249 )

• no red blood is evident in the vasculature of otherwise normal appearing males at E9.5 and E10.5

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