Phenotypes associated with this allele

• Allele Symbol: Dnmt1^tm1Enl
• Allele Name: targeted mutation 1, En Li
• Allele ID: MGI:1857601
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt1^tm1Enl/Dnmt1^tm1Enl	involves: 129S4/SvJae	MGI:2657163
hm2	Dnmt1^tm1Enl/Dnmt1^tm1Enl	involves: 129S4/SvJae * C57BL/6	MGI:3722086
cx3	Dnmt1^tm1Enl/Dnmt1^tm1Enl H19^tm1Tilg/H19^+	involves: 129S/SvEv * 129S4/SvJae	MGI:3712940

Genotype
MGI:2657163

hm1

• Allelic Composition: Dnmt1^tm1Enl/Dnmt1^tm1Enl
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:36234 )

nervous system

abnormal neural tube morphology ( J:36234 )

• distorted neural tube observed at E9.5

embryo

embryonic growth arrest ( J:36234 )

• growth is arrested prior to the 8-somite stage

abnormal neural tube morphology ( J:36234 )

• distorted neural tube observed at E9.5

absent somites ( J:36234 )

• lack visible somites at E9.5

cellular

abnormal DNA methylation ( J:36234 )

• DNA of endogenous C-type retroviruses and pericentromeric minor satellite repeats is highly demethylated with methylation level lower than in wild-type or Dnmt1^tm1Jae mice

Genotype
MGI:3722086

hm2

• Allelic Composition: Dnmt1^tm1Enl/Dnmt1^tm1Enl
• Genetic Background: involves: 129S4/SvJae * C57BL/6

cellular

abnormal DNA methylation ( J:116773 )

• most of the methylation patterns of repetitive sequences and Igf2r are lost

Genotype
MGI:3712940

cx3

• Allelic Composition: Dnmt1^tm1Enl/Dnmt1^tm1Enl; H19^tm1Tilg/H19⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae

cellular

genetic imprinting ( J:110857 )

• Ifg2 expression is normal indicating that imprinting is normal at this locus