All Phenotypes Hoxa4<tm1Bhr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa4^tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:1857628

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr	either: 129S/SvEv-Hoxa4^tm1Bhr or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2167813
ht2	Hoxa4^tm1Bhr/Hoxa4⁺	129S/SvEv-Hoxa4^tm1Bhr	MGI:3611207
ht3	Hoxa4^tm1Bhr/Hoxa4⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3611203
cx4	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxb4^tm1Bay/Hoxb4^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6	MGI:3611204
cx5	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxb4^tm1Bay/Hoxb4^tm1Bay Hoxd4^tm1Bhr/Hoxd4^tm1Bhr	involves: 129S/SvEv	MGI:3611055
cx6	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxd4^tm1Bhr/Hoxd4^tm1Bhr	involves: 129S/SvEv	MGI:3611052

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr
Genetic Background	either: 129S/SvEv-Hoxa4^tm1Bhr or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Homeotic transformation of C3 in Hoxa4^tm1Bhr/Hoxa4^tm1Bhr mice

skeleton

sternebra fusion ( J:22077 )

• 33% with 1-2 fused sternebrae

asymmetric rib joints ( J:22077 )

increased rib number ( J:22077 )

• 48% develop an extensive rib on the 7th cervical vertebra (C7), of these 20% are long enough to fuse to the costal cartilage of the T1 rib

cervical vertebral transformation ( J:22077 )

• extensive ribs on C7 in 48% of homozygotes

• processus spinus normally associated with C2 is also found on C3 in 71% of homozygotes

abnormal sternum ossification ( J:22077 )

• rarely, asymetrical ossification

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4⁺
Genetic Background	129S/SvEv-Hoxa4^tm1Bhr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:22077 )

• Background Sensitivity: C7 ribs are less common

abnormal cervical vertebrae morphology ( J:22077 )

• Background Sensitivity: C7 ribs are less common

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:22077 )

• Background Sensitivity: C7 ribs in 19% of heterozygotes

abnormal cervical vertebrae morphology ( J:22077 )

• Background Sensitivity: C7 ribs in 19% of heterozygotes

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxb4^tm1Bay/Hoxb4^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)
Hoxb4^tm1Bay mutation (1 available); any Hoxb4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:27467 )

• died within the first week of life

skeleton

abnormal cervical vertebrae morphology ( J:27467 )

• loss of lateral articulations between C2 and C3

• large processus spinosi on both C2 and C3

• C7 rib found in Hoxa4^tm1Bhr single homozygotes is not found

• anterior tuberculi shifted from C6 to C7

cervical vertebral fusion ( J:27467 )

• fusions of C2 and C3

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxb4^tm1Bay/Hoxb4^tm1Bay Hoxd4^tm1Bhr/Hoxd4^tm1Bhr
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cervical vertebrae morphology ( J:27467 )

• atlas like anterior arches on C1 through C5

• lateral foramina on C2, C3, and C4

cervical vertebral transformation ( J:27467 )

• C6 to C5 and C7 to C6 transformations

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxd4^tm1Bhr/Hoxd4^tm1Bhr
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)
Hoxd4^tm1Bhr mutation (0 available); any Hoxd4 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:27467 )

• C7 ribs

abnormal cervical vertebrae morphology ( J:27467 )

• dorsal cartilage between C2 and C3 fuses, penetrance 17%

• lateral ossified portions of C2 and C3 never fuse

• C7 ribs

cervical vertebral transformation ( J:27467 )

• large processus spinosi on both C2 and C3

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