All Phenotypes Mnm<C> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mnm^C
mildly affected
MGI:1857649

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J	MGI:3603516
cx2	Cmn1^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J	MGI:3612512
cx3	Cmn2^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J	MGI:3612513
cx4	Cmn3^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J	MGI:3612514
cx5	Cmn3^C57BL/6J/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J	MGI:3612515

Allelic Composition	Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C
Genetic Background	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2^nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Mnm^C mutation (0 available); any Mnm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:51890 , J:90418 )

• Background Sensitivity: survival to as long as 7 months of age, but less as the B6 component of the background increases (J:51890)

cardiovascular system

abnormal cardiovascular system physiology ( J:90418 )

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

abnormal impulse conducting system conduction ( J:90418 )

prolonged PR interval ( J:90418 )

• prolonged P-R interval

prolonged P wave ( J:90418 )

• sometimes split

prolonged QRS complex duration ( J:90418 )

nervous system

abnormal innervation pattern to muscle ( J:51890 )

• fewer dying neurons

motor neuron degeneration ( J:90418 )

• modest reduction in lumbar ventral root diameter

• 26% of L4 motor axons lost

• occasional dystrophic axons in ventral roots

• 25% loss of small caliber axons

behavior/neurological

decreased grip strength ( J:90418 )

• shorter latence to fall when suspended from a wire cage top

muscle

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

muscle degeneration ( J:90418 )

• moderate myopathic changes

muscular atrophy ( J:51890 )

• milder muscle atrophy

respiratory system

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )

decreased pulmonary respiratory rate ( J:90418 )

• reduced breathing rate (bradypnea)

growth/size/body

weight loss ( J:90418 )

homeostasis/metabolism

increased circulating creatine kinase level ( J:90418 )

• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )

Allelic Composition	Cmn1^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C
Genetic Background	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn1^CAST/Ei mutation (0 available); any Cmn1 mutation (0 available)
Ighmbp2^nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Mnm^C mutation (0 available); any Mnm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy

• increased survival time

muscle

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy

• increased survival time

Allelic Composition	Cmn2^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C
Genetic Background	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn2^CAST/Ei mutation (0 available); any Cmn2 mutation (0 available)
Ighmbp2^nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Mnm^C mutation (0 available); any Mnm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy

• increased survival time

muscle

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy

• increased survival time

Allelic Composition	Cmn3^CAST/Ei/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C
Genetic Background	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn3^CAST/Ei mutation (0 available); any Cmn3 mutation (0 available)
Ighmbp2^nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Mnm^C mutation (0 available); any Mnm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy in males

• increased survival time in males

muscle

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy in males

• increased survival time in males

Allelic Composition	Cmn3^C57BL/6J/? Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Mnm^C/Mnm^C
Genetic Background	involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn3^C57BL/6J mutation (0 available); any Cmn3 mutation (0 available)
Ighmbp2^nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Mnm^C mutation (0 available); any Mnm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy in females

• increased survival time in females

muscle

dilated cardiomyopathy ( J:102748 )

• resistance to dilated cardiomyopathy in females

• increased survival time in females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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