Phenotypes associated with this allele

• Allele Symbol: Il7^tm1Dnax
• Allele Name: targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
• Allele ID: MGI:1857652
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il7^tm1Dnax/Il7^tm1Dnax	involves: 129P2/OlaHsd	MGI:3769349
hm2	Il7^tm1Dnax/Il7^tm1Dnax	involves: 129P2/OlaHsd * C57BL/6	MGI:2180085
cx3	Il7^tm1Dnax/Il7^tm1Dnax Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129P2/OlaHsd * 129S/SvEv	MGI:3776482

Genotype
MGI:3769349

hm1

• Allelic Composition: Il7^tm1Dnax/Il7^tm1Dnax
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:64861 )

• at E14, thymocytes are about 100-fold lower than in heterozygous littermates

• however, differentiation of thymic progenitors into pro-T cells appears to be normal

hematopoietic system

decreased thymocyte number ( J:64861 )

• at E14, thymocytes are about 100-fold lower than in heterozygous littermates

• however, differentiation of thymic progenitors into pro-T cells appears to be normal

endocrine/exocrine glands

decreased thymocyte number ( J:64861 )

• at E14, thymocytes are about 100-fold lower than in heterozygous littermates

• however, differentiation of thymic progenitors into pro-T cells appears to be normal

Genotype
MGI:2180085

hm2

• Allelic Composition: Il7^tm1Dnax/Il7^tm1Dnax
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

small thymus ( J:24165 )

• thymus reduced in size and weight, but normal structure

decreased thymus weight ( J:24165 )

thymus hypoplasia ( J:24165 )

• reduced cellularity

arrested B cell differentiation ( J:24165 )

• lymphopoiesis blocked at pro-B to pre-B cell stage

decreased lymphocyte cell number ( J:24165 )

• lymphopenia

• retention of normal CD4 to CD8 ratio

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression on T cells is reduced by 60%

small spleen ( J:24165 )

• spleen reduced in size and weight, but retains the normal structure

decreased spleen weight ( J:24165 )

spleen hypoplasia ( J:24165 )

• reduced absolute numbers of both mature B and T cells in spleen

immune system

small thymus ( J:24165 )

• thymus reduced in size and weight, but normal structure

decreased thymus weight ( J:24165 )

thymus hypoplasia ( J:24165 )

• reduced cellularity

arrested B cell differentiation ( J:24165 )

• lymphopoiesis blocked at pro-B to pre-B cell stage

decreased lymphocyte cell number ( J:24165 )

• lymphopenia

• retention of normal CD4 to CD8 ratio

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression on T cells is reduced by 60%

small spleen ( J:24165 )

• spleen reduced in size and weight, but retains the normal structure

decreased spleen weight ( J:24165 )

spleen hypoplasia ( J:24165 )

• reduced absolute numbers of both mature B and T cells in spleen

absent Peyer's patches ( J:24165 )

• Peyer's patches undetected

absent lymph nodes ( J:24165 )

• lymph nodes undetected

endocrine/exocrine glands

small thymus ( J:24165 )

• thymus reduced in size and weight, but normal structure

decreased thymus weight ( J:24165 )

thymus hypoplasia ( J:24165 )

• reduced cellularity

Genotype
MGI:3776482

cx3

• Allelic Composition: Il7^tm1Dnax/Il7^tm1Dnax; Rag2^tm1Fwa/Rag2^tm1Fwa
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

immune system

decreased NK cell number ( J:132257 )

• 2-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice

hematopoietic system

decreased NK cell number ( J:132257 )

• 2-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice