All Phenotypes Bmp7<tm1Rob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp7^tm1Rob
targeted mutation 1, Elizabeth J Robertson
MGI:1857654

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp7^tm1Rob/Bmp7^tm1Rob	129S-Bmp7^tm1Rob	MGI:2451062
hm2	Bmp7^tm1Rob/Bmp7^tm1Rob	either: (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	MGI:2451064
cn3	Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700043
cn4	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700044
cn5	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700045
cn6	Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3768542
cx7	Bmp7^tm1Rob/Bmp7⁺ Fbn2^tm1Rmz/Fbn2⁺	either: (involves: 129/Sv * 129S/SvEv) or (involves: 129/Sv * 129S/SvEv * C57BL/6J)	MGI:3641531
cx8	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss	MGI:2451055
cx9	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6	MGI:2451053
cx10	Bmp7^tm1Rob/Bmp7^tm1Rob Bmpr1b^tm1Kml/Bmpr1b^tm1Kml	involves: 129S/SvEv * C57BL/6J	MGI:3789182

Allelic Composition	Bmp7^tm1Rob/Bmp7^tm1Rob
Genetic Background	129S-Bmp7^tm1Rob

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:30057 )

• ~95% die within a day of birth

• the remaining 5% die within 5-10 days of birth

• renal system failure is the putative reason for lethality

limbs/digits/tail

polydactyly ( J:30057 )

• ~33% exhbibited hind limb polydactyly, mixed background involving either C57BL/6J or MF1

• 1 mouse (of 14) was observed with hind limb polydactyly on the 129S/SvEv background

renal/urinary system

abnormal kidney development ( J:30057 )

• bilateral renal dysplasia

• observed in both inbred and mixed backgrounds

hydroureter ( J:30057 )

• often accompanying renal dysplasia

vision/eye

microphthalmia ( J:30057 )

• ~20% exhibited bilateral microphthalmia

• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia

• proportions observed on both inbred and mixed genetic backgrounds

anophthalmia ( J:30057 )

• ~60% exhibited bilateral anophthalmia

• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia

• proportions observed on both inbred and mixed genetic backgrounds

craniofacial

abnormal cranium morphology ( J:30057 )

• occasionally, membranous bones in cranial region are not fully developed

nervous system

exencephaly ( J:30057 )

• exencephaly is observed in very low percentage of late stage or perinatal mutant mice

skeleton

abnormal axial skeleton morphology ( J:30057 )

• about 50% of mice display minor axial skeletal abnormalities

abnormal cranium morphology ( J:30057 )

• occasionally, membranous bones in cranial region are not fully developed

abnormal sternocostal joint morphology ( J:30057 )

• prevalent axial skeletal defect is failure of one or both of seventh rib pair to fuse to sternum, usually accompanied by absence of an obvious fourth sternebral ossification center

Allelic Composition	Bmp7^tm1Rob/Bmp7^tm1Rob
Genetic Background	either: (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:30057 )

• ~95% die within a day of birth

• the remaining 5% die within 5-10 days of birth

limbs/digits/tail

polydactyly ( J:30057 )

• ~33% exhbibited hind limb polydactyly, mixed background involving either C57BL/6J or MF1

• 1 mouse (of 14) was observed with hind limb polydactyly on the 129S/SvEv background

renal/urinary system

abnormal kidney development ( J:30057 )

• bilateral renal dysplasia

• observed in both inbred and mixed backgrounds

hydroureter ( J:30057 )

• often accompanying renal dysplasia

vision/eye

microphthalmia ( J:30057 )

• ~20% exhibited bilateral microphthalmia

• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia

• proportions observed on both inbred and mixed genetic backgrounds

anophthalmia ( J:30057 )

• ~60% exhibited bilateral anophthalmia

• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia

• proportions observed on both inbred and mixed genetic backgrounds

skeleton

abnormal axial skeleton morphology ( J:30057 )

• about 50% of mice display minor axial skeletal abnormalities

abnormal cranium morphology ( J:30057 )

• occasionally, membranous bones in cranial region are not fully developed

abnormal sternocostal joint morphology ( J:30057 )

• prevalent axial skeletal defect is failure of one or both of seventh rib pair to fuse to sternum, usually accompanied by absence of an obvious fourth sternebral ossification center

craniofacial

abnormal cranium morphology ( J:30057 )

• occasionally, membranous bones in cranial region are not fully developed

nervous system

exencephaly ( J:30057 )

• exencephaly is observed in very low percentage of late stage or perinatal mutant mice

Allelic Composition	Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal scapula morphology ( J:118257 )

• mice show a scapular defect

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants are completely like wild-type in skeletal pattern and differentiation

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants are completely like wild-type in skeletal pattern and differentiation

Allelic Composition	Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail

abnormal phalanx morphology ( J:118257 )

• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb

abnormal fibula morphology ( J:118257 )

• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee

skeleton

abnormal appendicular skeleton morphology ( J:118257 )

• overall size of the appendicular skeleton is slightly diminished

abnormal phalanx morphology ( J:118257 )

• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb

abnormal fibula morphology ( J:118257 )

• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee

abnormal scapula morphology ( J:118257 )

• scapular defect

Allelic Composition	Bmp7^tm1Rob/Bmp7⁺ Fbn2^tm1Rmz/Fbn2⁺
Genetic Background	either: (involves: 129/Sv * 129S/SvEv) or (involves: 129/Sv * 129S/SvEv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)
Fbn2^tm1Rmz mutation (1 available); any Fbn2 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polysyndactyly ( J:70592 )

Allelic Composition	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:78867 )

• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

reproductive system

decreased testis weight ( J:78867 )

• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

abnormal epididymis morphology ( J:78867 )

• similar epididymal phenotype as Bmp8a^tm1Blh homozygous mutant mice

Allelic Composition	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

granulomatous inflammation ( J:78867 )

• granuloma formation more pronounced than in Bmp8a^tm1Blh homozygous mutant mice

reproductive system

abnormal male germ cell morphology ( J:78867 )

• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

abnormal spermatogenesis ( J:78867 )

abnormal epididymis morphology ( J:78867 )

• blockage and accumulation of sperm

epididymis degeneration ( J:78867 )

• 67% exhibited severe epididymal degeneration

epididymis epithelium degeneration ( J:78867 )

male infertility ( J:78867 )

• 75% of male mice were infertile

cellular

abnormal male germ cell morphology ( J:78867 )

• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

Allelic Composition	Bmp7^tm1Rob/Bmp7^tm1Rob Bmpr1b^tm1Kml/Bmpr1b^tm1Kml
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)
Bmpr1b^tm1Kml mutation (0 available); any Bmpr1b mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased autopod size ( J:59282 )

• within the forelimb autopod, every element, except for the distal phalanx, is severely reduced or absent

brachyphalangia ( J:59282 )

• the phalanges are severely reduced

abnormal humerus morphology ( J:59282 )

• the trochanter of the humerus is absent

short humerus ( J:59282 )

short radius ( J:59282 )

short ulna ( J:59282 )

• ulna is nearly absent

short metacarpal bones ( J:59282 )

• the metacarpals are severely reduced

skeleton

brachyphalangia ( J:59282 )

• the phalanges are severely reduced

abnormal humerus morphology ( J:59282 )

• the trochanter of the humerus is absent

short humerus ( J:59282 )

short radius ( J:59282 )

short ulna ( J:59282 )

• ulna is nearly absent

short metacarpal bones ( J:59282 )

• the metacarpals are severely reduced

abnormal scapula morphology ( J:59282 )

• width of the dorsal margin of the scapula is reduced

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