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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		LnpkUl
ulnaless
MGI:1857660
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		LnpkUl/LnpkUl involves: C3H/HeJ * C57BL/6J * FVB/N MGI:4361020
hm2
 		LnpkUl/LnpkUl involves: C3H/HeJ * C57BL/6J * MOLF/Ei MGI:4361021
ht3
 		LnpkUl/Lnpk+ B6EiC3-+ a/LnpkUl A/J MGI:3707364
ht4
 		LnpkUl/Lnpk+ involves: 101/H * C3H/HeJ MGI:3582529
ht5
 		LnpkUl/Lnpk+ involves: 101/H * C3H/HeJ * C57BL/6J MGI:3582532
ht6
 		LnpkUl/Lnpk+ involves: C3H/HeJ * C57BL/6J * FVB/N MGI:4361308


Genotype
MGI:4361020
hm1
Allelic
Composition		 LnpkUl/LnpkUl
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:37225 )
• Background Sensitivity: although the anticipated 1:2:1 Mendelian ratio is obtained at birth from heterozygous intercrosses, very few homozygotes are found at wean age on this predominantly FVB/N background, and those that do survive are male, but this loss of homozygotes is not gound on a predominantly MOLF/Ei background

limbs/digits/tail
abnormal limb morphology ( J:37225 )
• homozygotes have a more severe reduction of the ulna and radius than heterozygotes and there is a severe loss of the fibula and severe reduction and bowing of the tibia

skeleton
delayed bone ossification ( J:37225 )
• the ossification centers of the ulna and fibula are absent in homozygous neonates




Genotype
MGI:4361021
hm2
Allelic
Composition		 LnpkUl/LnpkUl
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * MOLF/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb morphology ( J:37225 )
• homozygotes have a more severe reduction of the ulna and radius than heterozygotes and there is a severe loss of the fibula and severe reduction and bowing of the tibia

skeleton
delayed bone ossification ( J:37225 )
• the ossification centers of the ulna and fibula are absent in homozygous neonates




Genotype
MGI:3707364
ht3
Allelic
Composition		 LnpkUl/Lnpk+
Genetic
Background		 B6EiC3-+ a/LnpkUl A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased bleeding time ( J:31800 )
• bleeding time is increased 2.6- to 3-fold compared to controls
• platelet numbers and function appear normal




Genotype
MGI:3582529
ht4
Allelic
Composition		 LnpkUl/Lnpk+
Genetic
Background		 involves: 101/H * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased radius size ( J:13461 )
• extreme reduction
short ulna ( J:13461 )
• extreme reduction
abnormal tibia morphology ( J:13461 )
• deformities

skeleton
decreased radius size ( J:13461 )
• extreme reduction
short ulna ( J:13461 )
• extreme reduction
abnormal tibia morphology ( J:13461 )
• deformities

reproductive system
male infertility ( J:13461 )
• males do not breed




Genotype
MGI:3582532
ht5
Allelic
Composition		 LnpkUl/Lnpk+
Genetic
Background		 involves: 101/H * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased radius size ( J:10491 )
• extreme reduction
short ulna ( J:10491 )
• extreme reduction
abnormal fibula morphology ( J:10491 )
• fibula is rotated 90 degrees
• fibula is detached from the tibia proximally
abnormal tibia morphology ( J:10491 )
• rotated 90 degrees
abnormal metacarpal bone morphology ( J:10491 )
• articulations to distal ends of long bones are abnormal
abnormal metatarsal bone morphology ( J:10491 )
• articulations to distal ends of long bones are abnormal

skeleton
decreased radius size ( J:10491 )
• extreme reduction
short ulna ( J:10491 )
• extreme reduction
abnormal fibula morphology ( J:10491 )
• fibula is rotated 90 degrees
• fibula is detached from the tibia proximally
abnormal tibia morphology ( J:10491 )
• rotated 90 degrees
abnormal metacarpal bone morphology ( J:10491 )
• articulations to distal ends of long bones are abnormal
abnormal metatarsal bone morphology ( J:10491 )
• articulations to distal ends of long bones are abnormal

reproductive system
male infertility ( J:10491 )
• males do not breed although females breed well
• spermatogenesis unimpaired




Genotype
MGI:4361308
ht6
Allelic
Composition		 LnpkUl/Lnpk+
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LnpkUl mutation (1 available); any Lnpk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:37225 )
• Background Sensitivity: at weaning there are fewer heterozygotes, both male and female, than expeted from heterozygote x FVB/N matings on a predominantly FVB/N background, but not on a predominantly MOLF/Ei background




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory