limbs/digits/tail
• some mice display bone fusions in the paws
|
• at birth, paw size is noticeably reduced
|
• at birth, digit size is noticeably reduced
(J:36443)
• secondary fusions between proximal digital elements results in Y-like digits or polysyndactyly
(J:36443)
• toe 1 is malformed
(J:153164)
|
• distal elements of digits are dramatically reduced in size
(J:36443)
• in all digits
(J:153164)
|
ectrodactyly
(
J:71694
)
• both fore- and hindpaws have markedly shorter digits with absence of the second phalanges and an abnormal aspect of the digits, and the ectrodactyly in the hindpaw is less severe than in the hindpaw of Doxd13
|
• conspicuous at birth
(J:36443)
• additional digits are intercalated or fused, to either digit III or IV; invariably, animals have six defective and partially fused digits
(J:36443)
• observed in the hindpaw of most, if not all, homozygotes
(J:71694)
• in the hind limbs
(J:153164)
|
• at E11 and E12, presumptive digit area is reduced in size
|
• at birth, webbing between vestigal digits is observed in all homozygotes
|
skeleton
• cartilage remodeling in newborn animals is significantly delayed; characteristic columns of quiescent cells normally seen in controls are rarely apparent in mutants
|
cellular
• at birth, webbing between vestigal digits is observed in all homozygotes
|