All Phenotypes Myog<tm1Whk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myog^tm1Whk
targeted mutation 1, William H Klein
MGI:1857667

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myog^tm1Whk/Myog^tm1Whk	involves: 129S7/SvEvBrd	MGI:3654907
hm2	Myog^tm1Whk/Myog^tm1Whk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2175134
ht3	Myog^tm1Sjb/Myog^tm1Whk	involves: 129	MGI:3036569
ht4	Myog^tm1Whk/Myog^tm2Whk	involves: 129S7/SvEvBrd * C57BL/6	MGI:3656058
cx5	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714517
cx6	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714518
cx7	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714533
cx8	Myf6^tm1Eno/Myf6^tm1Eno Myog^tm1Whk/Myog^tm1Whk	involves: 129S7/SvEvBrd * C57BL/6	MGI:3714502

Allelic Composition	Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal myoblast differentiation ( J:22984 )

• at E12.5 desmin staining is weaker and myosin heavy polypeptide staining is absent suggesting a delay in myoblast differentiation

• at E14.5 myoblasts appear to persist in muscle forming regions suggesting incomplete differentiation

mortality/aging

neonatal lethality, complete penetrance ( J:110733 )

muscle

abnormal laryngeal muscle morphology ( J:110733 )

• undetectable

abnormal muscle development ( J:22984 )

abnormal myogenesis ( J:22984 )

• after E15.5 somitic muscle forming regions are greatly reduced in mass, myofibers are more diffuse and stain less intensely for myosin heavy polypeptide and at E16.5 myofiber numbers are reduced compared to wild-type

abnormal myoblast differentiation ( J:22984 )

• at E12.5 desmin staining is weaker and myosin heavy polypeptide staining is absent suggesting a delay in myoblast differentiation

• at E14.5 myoblasts appear to persist in muscle forming regions suggesting incomplete differentiation

thin diaphragm muscle ( J:110733 )

• thin and fibrous but intact

muscle hypoplasia ( J:22984 , J:110733 )

• at E18.5 muscles in the back, ventral-lateral body wall, and forelimb have far fewer muscle fibers compared to control littermates; however, the ratio of fast to slow fibers is similar to controls and all muscle groups that make up the crural region of the hindlimb are present despite the reduction in fiber number (J:22984)

growth/size/body

abnormal laryngeal muscle morphology ( J:110733 )

• undetectable

respiratory system

abnormal laryngeal muscle morphology ( J:110733 )

• undetectable

abnormal lung development ( J:110733 )

• at E20, lungs appear to have arrested at the canalicular stage and retain cuboidal respiratory epithelium

• at E20, increased apoptosis is seen primarily in the bronchial or mesenchymal cells; however no change in apoptosis is seen in the heart or liver

pulmonary hypoplasia ( J:110733 )

• ratio of wet lung weight to body weight is reduced at E14, E17, and E20; however lung lobe structure is similar to wild-type

• at E14, intrathoracic spaces are about 30% smaller compared to age-matched littermates

• at E14 and E17, BrdU and PCNA labeling indicate a decrease in proliferation and proliferation rates in the mesenchymal and epithelial compartments are similar unlike in control littermates

• DNA content at term (E20) is reduced by about 20% compared to control littermates

respiratory failure ( J:110733 )

• no respiratory movements

behavior/neurological

abnormal reflex ( J:110733 )

• lack withdrawal reflexes at E17, E19, and E20 (full term)

no spontaneous movement ( J:110733 )

homeostasis/metabolism

cyanosis ( J:110733 )

• develops within seconds of birth

skeleton

kyphosis ( J:110733 )

embryo

embryo phenotype ( J:110733 )

N	• amniotic fluid volume appears normal

Allelic Composition	Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:14208 )

• die within minutes of birth; however a heart beat is detected at birth

respiratory system

respiratory failure ( J:14208 )

muscle

thin diaphragm muscle ( J:14208 )

• extremely thin

decreased skeletal muscle mass ( J:14208 )

• decreased mass throughout the body, particularly in the tongue and diaphragm

• however, smooth muscle of the aorta and digestive tract appears normal and differentiated cardiomyocytes are present

decreased skeletal muscle fiber density ( J:14208 )

• reduced fiber density, particularly evident in the tongue and diaphragm but also in the trunk and facial areas

muscle hypoplasia ( J:14208 )

• areas normally occupied by myofibers contain mostly mononucleate cells; however, the number of nuclei in muscle-forming regions is similar to wild-type

behavior/neurological

unresponsive to tactile stimuli ( J:14208 )

no spontaneous movement ( J:14208 )

skeleton

abnormal sternebra size ( J:14208 )

• the cranial most sternebrae are wider and the caudal most are narrower than in wild-type mice

short sternum ( J:14208 )

• 55% shorter than in wild-type

abnormal rib morphology ( J:14208 )

• abnormal curvature, and aligned perpendicularly to the vertebral and sternebral bodies

• the second pair of ribs displays delayed or absent connection to the manubrium

short ribs ( J:14208 )

• 15% shorter than in wild-type mice

kyphosis ( J:14208 )

abnormal sternum ossification ( J:14208 )

• excessively ossified with reduced or absent intersternebral cartilage

fragile skeleton ( J:14208 )

adipose tissue

increased brown adipose tissue amount ( J:14208 )

• especially in the dorsal cervical region resulting in visible thickening of the dorsal neck area

homeostasis/metabolism

cyanosis ( J:14208 )

Allelic Composition	Myog^tm1Sjb/Myog^tm1Whk
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myog^tm1Sjb mutation (0 available); any Myog mutation (14 available)
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:88178 )

• although homozygous null mice die perinatally, these mice appear healthy and survive to adulthood

Allelic Composition	Myog^tm1Whk/Myog^tm2Whk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)
Myog^tm2Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:54065 )

• die at birth

homeostasis/metabolism

edema ( J:54065 )

muscle

muscle hypoplasia ( J:54065 )

• severe

skeleton

abnormal sternum morphology ( J:54065 )

• fused and ossified

kyphosis ( J:54065 )

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48809 )

• mutants are normal, viable and fertile and appear to have normal muscle

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:48809 )

• myogenesis is arrested at the level seen in single homozygous Myog mutants

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:61155 )

• die within minutes of birth

growth/size/body

decreased fetal size ( J:61155 )

• E18.5 mutants show a reduction in body mass

muscle

abnormal muscle development ( J:61155 )

• marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers

• myoblasts from neonates are unable to differentiate in vitro

muscle hypoplasia ( J:61155 )

• severe muscle deficiency with almost no muscle fibers; the few fibers that are present are extremely thin and underdeveloped

• tongue, back, limb, and skeletal muscle are all affected comparably unlike in single Myog homozygous mutants

skeleton

abnormal rib morphology ( J:61155 )

• the average lengths of the ossified portions of the ribs are 30% shorter than normal at E15.5, however the ribs reach the sternum

kyphosis ( J:61155 )

• severe

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• lethality at birth; mutants exhibit reduced levels of Myf5 mRNA unlike single Myf6^tm1Eno homozygotes

muscle

abnormal muscle fiber morphology ( J:48809 )

• exhibit a deficiency in muscle fibers showing only residual differentiated muscle fibers, however the number of these residual fibers is similar to that seen in Myog homozygotes

muscle hypoplasia ( J:48809 )

• exhibit a deficiency in muscle fibers

skeleton

abnormal sternebra morphology ( J:48809 )

• sternebral bodies are severely malformed

abnormal sternocostal joint morphology ( J:48809 )

• distal portions of the ribs fail to reach the sternum

split sternum ( J:48809 )

• upper region of the sternum is bifurcated

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