Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cdh5tm1Hub targeted mutation 1, Philippe Huber MGI:1857669 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• vessels of the allantois and endocardium are abnormal at E8.5 while at this time the dorsal aorta appears normal; however by E9.5 the dorsal aorta is abnormal suggesting that vessels initially form properly but rapidly deteriorate
• allantois explant cultures from E8.5 embryos fail to develop interconnected vessels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• death between E9.5 and E11.5
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• at E9.25, in the caudal part of the embryo the dorsal aorta is dilated
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• at E9.25, in the caudal part of the embryo the umbilical artery is dilated
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• at E9.25, limited angiogenic extensions (ie intersomitic vessels) are present
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• at E9.25, limited angiogenic extensions (ie intersomitic vessels) are present and the head microcirculation is only partially developed
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• at E8.5, embryonic vascularization is delayed with incomplete formation of the dorsal aortae in the caudal region, presence of the sinus venosus but absence of the posterior cardinal veins, and no PECAM staining rostral of the cardiac region; however vessel formation occurs in the caudal region
• at E8.5, endocardium is present but endothelial cells fail to form a lumen
• at E9.25, a vascular plexus is present but no organized large vessels are present
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• endothelial cells along the vitello-embryonic stalk assemble into vesicles but do not form continuous vessels
• blood islands form and primary hematopoeisis is normal but failure of primary vascular plexus formation prevents normal blood circulation so that no primitive erythrocytes are seen in the embryo
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• at E10.5, distended pericardial cavity
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• at E10.5 the heart beat is irregular and weak
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• endothelial cells along the vitello-embryonic stalk assemble into vesicles but do not form continuous vessels
• blood islands form and primary hematopoeisis is normal but failure of primary vascular plexus formation prevents normal blood circulation so that no primitive erythrocytes are seen in the embryo
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• at E10.5
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• at E10.5
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• at E10.5 there are never more than 20 somites compared to 35 in wild-type mice
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• at E9.25, umbilical vessels do not penetrate the allantois; however vascular organization of the placenta is normal
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• at E9.25, in the caudal part of the embryo the umbilical artery is dilated
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• blood islands are concentrated in the placental hemisphere of the yolk sac with very few blood cells present in the embryonic hemisphere
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• extensive cell death is seen beginning at E9.5
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• at E10.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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