Phenotypes associated with this allele

• Allele Symbol: Vcan^{Tg(Hoxa1)1Chm}
• Allele Name: transgene insertion 1, Corey H Mjaatvedt
• Allele ID: MGI:1857689
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vcan^Tg(Hoxa1)1Chm/Vcan^Tg(Hoxa1)1Chm	involves: C57BL/6J * CBA	MGI:2175821
cx2	Adamts9^tm1Dgen/Adamts9^tm1Dgen Vcan^Tg(Hoxa1)1Chm/Vcan^+	B6.Cg-Adamts9^tm1Dgen Vcan^Tg(Hoxa1)1Chm	MGI:4418862

Genotype
MGI:2175821

hm1

• Allelic Composition: Vcan^{Tg(Hoxa1)1Chm}/Vcan^{Tg(Hoxa1)1Chm}
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:41016 )

• lethality around E10.5

cardiovascular system

abnormal heart development ( J:41016 )

• cardiac defects along the anterior-posterior axis

• primitive outlet segments of the heart, consisting of the primitive right ventricle and the conus, appear underdeveloped

• stenosis of the anterior limb of the looped heart

absent conotruncal ridges ( J:41016 )

• endocardial cushions in the conus regions are missing

absent atrioventricular cushions ( J:41016 )

• endocardial cushions in the atrioventricular regions are missing

abnormal heart right ventricle morphology ( J:41016 )

• primitive right ventricle is constricted and appears underdeveloped

dilated heart ( J:41016 )

• the primitive inlet portion of the heart, comprising the left ventricle, atrioventricular, and atrial segments, is highly dilated

dilated heart atrium ( J:41016 )

dilated heart left ventricle ( J:41016 )

embryo

decreased embryo size ( J:41016 )

growth/size/body

decreased embryo size ( J:41016 )

Genotype
MGI:4418862

cx2

• Allelic Composition: Adamts9^tm1Dgen/Adamts9^tm1Dgen; Vcan^{Tg(Hoxa1)1Chm}/Vcan⁺
• Genetic Background: B6.Cg-Adamts9^tm1Dgen Vcan^{Tg(Hoxa1)1Chm}

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )