mortality/aging
• die between E8.5 and E10.5
|
embryo
• E7.5 embryos exhibit an increase in apoptotic cells
|
• epiblast contains numerous pyknotic nuclei
|
• at E8.5, embryos appear underdeveloped and have not progressed beyond the E7.5 egg cylinder stage, however E6.5 embryos are indistinguishable from wild-type
|
• egg cylinders are smaller and stubby at E7.5
|
• despite the formation of the three germ layers, embryos do not expand normally, are disorganized, and exhibit dense, amorphous masses of cells in some areas
|
• at E8.5, the amniotic cavity often contains dead cells with pyknotic nuclei
|
• at E8.5, the amniotic cavity is small
|
• thicker Reichert's membrane that exhibits many interspersed nodules covered with clusters of parietal cells
|
• extraembryonic portion of the E7.5 embryo appears folded and disorganized
|
• the surface of the visceral endoderm consists of semi-spherical blebs due to numerous invaginations
|
cellular
• E7.5 embryos exhibit an increase in apoptotic cells
|
• epiblast contains numerous pyknotic nuclei
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | Huntington's disease | DOID:12858 |
OMIM:143100 |
J:29267 |