All Phenotypes Tlr4<lps-n> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr4^lps-n
normal lipopolysaccharide response
MGI:1857731

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr4^lps-n/Tlr4^lps-n	C3H/HeN	MGI:4412004

Allelic Composition	Tlr4^lps-n/Tlr4^lps-n
Genetic Background	C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4^lps-n mutation (0 available); any Tlr4 mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:5557 )

N	• mice are responsive to LPS stimulation

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment

decreased acute inflammation ( J:37271 )

• distinctly lower endotoxin levels after 7 days of dextran sodium sulfate treatment compared to C3H/HeJ mice carrying the Tlr4^Lps-d allele

hematopoietic system

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment

growth/size/body

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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