Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cnr1tm1Map targeted mutation 1, Marc Parmentier MGI:1857736 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fail to exhibit the 2-arachidonoyl glycerol sweet enhancing nerve response and increased licking unlike in wild-type mice
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• mice fail to exhibit the 2-arachidonoyl glycerol sweet enhancing nerve response unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased motile spermatozoa in the caput compared with wild-type mice
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• mice exhibit increased motile spermatozoa in the caput compared with wild-type mice
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| N |
• osteoclast and osteoblast numbers are normal
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• ovariectomized mice do not exhibit a decrease in bone mineral density unlike similarly treated wild-type mice
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• in the spine, spine, and tibial metaphysis
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• mice fail to exhibit depolarization-induced suppression of inhibition unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice
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• unlike in wild-type mice, there is no decrease in horizontal locomotor activity or rectal temperature following treatment with delta9-tetrahydrocannabinol (delta9-THC)
• in an intravenous self-administration model, the number of nose pokes leading to WIN55,212-2 administration are reduced compared to wild-type mice
• unlike in wild-type mice, there is no abstinence when treated with the Cnr1-receptor antagonist SR141.716A following long term exposure to delta-THC
• unlike wild-type mice, there is no hypotensive response to anandamide or WIN55,212-2
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• in an intravenous self-administration model, the number of nose pokes leading to morphine administration are reduced compared to wild-type mice
• naloxine-precipitated morphine withdrawal symptoms are decreased compared to in wild-type mice
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• in an active avoidance test, mice exhibit increased conditioned responses compared with wild-type mice
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• the dysphoric effect on conditioned place aversion by U-50,488H is not observed in mutant mice
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• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice
• mice exhibit increased exploratory behavior under stressful conditions of an open field and in the spontaneous alteration test (58.9+/-2.2 visits to the arms compared to 47.2+/-1.6 visits to the arms for wild-type mice)
• mice exhibit a decrease in spontaneous alternations in a Y maze (53.7+/-1.9% compared to 61.4+/-1.8% for wild-type mice)
• however, the number of entries and time spent in the open arms in an elevated plus maze are normal
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• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice
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• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice
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• in an elevated plus maze, mice spend less time exploring open arms compared with wild-type mice
(J:89437)
• however, mice treated with the cannabinoid antagonist SR141716A exhibit a normal reduction in anxiety
(J:89437)
• under high light conditions, mice exhibit increased anxiety-related behavior in an elevated plus maze compared with wild-type mice
(J:89722)
• however, behavior in an elevated plus maze under low light conditions is normal
(J:89722)
• in a light/dark box
(J:103942)
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• time spent exploring an unknown object is increased (5.33+/-1.5 s compared to 0.66+/-0.3 s for wild-type mice)
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• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice
• however, activity levels are normal after habituation
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• the antinociception effect of delta9-tetrahydrocannabinol (THC) is abolished when mice are subjected to a hot-plate test and strongly reduced when subjected to a tail-immersion test
• however, the antinociceptive effect of morphine and U-50,488H and the tolerance development for morphine are unaltered
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• in an unfamiliar cage, mice exhibit decreased social interaction compared with wild-type mice
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• mice exhibit increased aggression towards other mice in a home cage compared with wild-type mice
(J:89722)
• in a resident-intruder test
(J:103942)
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• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
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• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice
• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice
• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice
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• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice
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• following middle cerebral artery occlusion (MCA)
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• basal and stress-induced
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• slightly but significantly more sensitive to 3NP intoxication
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• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
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• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice
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• following middle cerebral artery occlusion (MCA)
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• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
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• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice
• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice
• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following middle cerebral artery occlusion (MCA)
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• following middle cerebral artery occlusion (MCA)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• despite similar disease progression, mice exhibit longer life span compared with Tg(SOD1*G93A)1Gur mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced lifespan compared to wild-type controls
• however lifespan is similar to transgenic mice wild-type for Cnr1
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• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1
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• reduced latency to fall and an increased number of falls in a rotarod assay
• motor performance is worse than in transgenic mice wild-type for Cnr1
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• fail to gain weight after 16 weeks of age
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• fail to gain weight after 16 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Huntington's disease | DOID:12858 |
OMIM:143100 |
J:172874 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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