Analysis Tools
pigmentation
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• white coat with some dark pigmentation on the ears and occasional pigmented spot on the rump
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reproductive system
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• at P12, mutant ovaries contain significantly fewer oocytes than wild-type ovaries
• at P12, homozygotes show a 6- to 8-fold reduction in the number of primordial (resting) and growing oocytes relative to wild-type controls
• at 7 months of age, no oocytes or follicular tissue are observed
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• at P12, mutant seminiferous tubules contain fewer and less differentiated germ cells than wild-type tubules
• by 5 weeks of age, mutant tubules contain only a few germ cells and show virtual cessation of spermatogenesis
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• at E11.5 and E12.5, PGC numbers are reduced to 18-24% and ~6%, respectively, of those in wild-type controls; both sexes are equally affected
(J:2880)
• unlike in wild-type controls, PGC numbers are decreased from E11.5 to E12.5, suggesting that both PGC survival and/or proliferation may be impaired
(J:2880)
• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and KitlSl-gb homozygotes at E11.5
(J:115437)
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small ovary
(
J:2880
)
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• at P12, mutant ovaries are significantly smaller than wild-type
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• hyperplasia of the interstitial cells is observed at 5 weeks of age
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• delayed onset and reduction in numbers of germ cells
• depletion of differentiating germ cells by 8 weeks of age
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• male, but not female, homozygotes are sterile
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endocrine/exocrine glands
small ovary
(
J:2880
)
|
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• at P12, mutant ovaries are significantly smaller than wild-type
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• hyperplasia of the interstitial cells is observed at 5 weeks of age
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neoplasm
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• at 7 months of age, mutant ovaries exhibit large invaginations of the surface epithelium, an extensive network of complex tubular adenoma and fat infiltration
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integument
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• white coat with some dark pigmentation on the ears and occasional pigmented spot on the rump
|
cellular
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|
• at P12, mutant ovaries contain significantly fewer oocytes than wild-type ovaries
• at P12, homozygotes show a 6- to 8-fold reduction in the number of primordial (resting) and growing oocytes relative to wild-type controls
• at 7 months of age, no oocytes or follicular tissue are observed
|
|
|
• at P12, mutant seminiferous tubules contain fewer and less differentiated germ cells than wild-type tubules
• by 5 weeks of age, mutant tubules contain only a few germ cells and show virtual cessation of spermatogenesis
|
|
• at E11.5 and E12.5, PGC numbers are reduced to 18-24% and ~6%, respectively, of those in wild-type controls; both sexes are equally affected
(J:2880)
• unlike in wild-type controls, PGC numbers are decreased from E11.5 to E12.5, suggesting that both PGC survival and/or proliferation may be impaired
(J:2880)
• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and KitlSl-gb homozygotes at E11.5
(J:115437)
|
