Phenotypes associated with this allele

• Allele Symbol: Map2k3^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:1857752
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k3^tm1Flv/Map2k3^tm1Flv	B6.129S1-Map2k3^tm1Flv	MGI:3722768
hm2	Map2k3^tm1Flv/Map2k3^tm1Flv	involves: 129S1/Sv	MGI:3580446

Genotype
MGI:3722768

hm1

• Allelic Composition: Map2k3^tm1Flv/Map2k3^tm1Flv
• Genetic Background: B6.129S1-Map2k3^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124327 )

• following infection with live Streptococcus pneumoniae, 80% of mice are dead by day 5 and 100% at day 7 compared to 25% and 66% at the same time points for infected wild-type mice

• following infection with S. pneumoniae wild-type lysate and S. pneumoniae pneumolysin (PLY), mice begin to die within hours of infection and all mice are dead by 6 hours

immune system

increased susceptibility to bacterial infection ( J:124327 )

• following infection with live Streptococcus pneumoniae, 80% of mice are dead by day 5 and 100% at day 7 compared to 25% and 66% at the same time points for infected wild-type mice

• following infection with S. pneumoniae wild-type lysate and S. pneumoniae pneumolysin (PLY), mice begin to die within hours of infection and all mice are dead by 6 hours

• following infection with S. pneumoniae, mice exhibit more massive alveolar hemorrhage compared to infected wild-type mice

Genotype
MGI:3580446

hm2

• Allelic Composition: Map2k3^tm1Flv/Map2k3^tm1Flv
• Genetic Background: involves: 129S1/Sv

immune system

decreased T cell apoptosis ( J:85266 )

• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )

• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

cellular

decreased T cell apoptosis ( J:85266 )

• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

hematopoietic system

decreased T cell apoptosis ( J:85266 )

• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )

• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis