Phenotypes associated with this allele

• Allele Symbol: T2^Tg(H2K)1Art
• Allele Name: transgene insertion 1, Karen Artzt
• Allele ID: MGI:1857754
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	T2^Tg(H2K)1Art/T2^Tg(H2K)1Art	involves: C57BL/10 * BTNTTF * CBA	MGI:3834560
ht2	T2^Tg(H2K)1Art/T2^+	involves: C57BL/10 * BTNTTF * CBA	MGI:3834561

Genotype
MGI:3834560

hm1

• Allelic Composition: T2^Tg(H2K)1Art/T2^Tg(H2K)1Art
• Genetic Background: involves: C57BL/10 * BTNTTF * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:29666 )

• at E11-11.5 most of the abnormal embryos are moribund

• although there is an allantoic connection, death is shortly after E11.5 when development ceases

embryo

embryonic growth retardation ( J:29666 )

absent notochord ( J:29666 )

• floor plate may be present even in absence of the notochord

growth/size/body

embryonic growth retardation ( J:29666 )

cardiovascular system

abnormal heart development ( J:29666 )

• 15-20 percent of homozygous embryos have heart defects

abnormal heart tube morphology ( J:29666 )

• the heart tube leaves the body cavity and makes two right angles before returning to the body cavity

• in may cases the heart tube does not fold

limbs/digits/tail

absent tail ( J:29666 )

• E10.5 embryos are tailless

Genotype
MGI:3834561

ht2

• Allelic Composition: T2^Tg(H2K)1Art/T2⁺
• Genetic Background: involves: C57BL/10 * BTNTTF * CBA

limbs/digits/tail

short tail ( J:29666 )

• tail length is 90% of normal, varying in a narrow range

• incomplete penetrance in 7% of carriers from heterozygote by wild-type matings

kinked tail ( J:29666 )

• occasional kink at end of tail