Analysis Tools
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased susceptibility to mycobacterial infection during the early but not the late phase of acquired immunity
• rapid, uncontrolled bacterial proliferation in the early phase of BCG infection, reaching a maximum at 3 wk
• the spleen BCG load was decreased at 6 weeks after infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased susceptibility to mycobacterial infection during the early but not the late phase of acquired immunity
• after initial infection with 103 Salmonella enteriditis CFUs, spleen bacterial loads declined sharply by day 21, and were nearly undetectable by day 42 postinfection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• little or no bacterial proliferation was observed in the spleen at any time following BCG inoculation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 42 days after IV injection of 103 Salmonella enteritidis CFUs, spleen CFU levels were intermediate to those in C57BL/6J and 129/Sv
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compound heterozygous mice were susceptible to early phase infection with BCG or L. donovani or S. typhimurium
• mice showed rapid early BCG proliferation, a maximum bacterial load peaking at 3 weeks, and reduction of the BCG load by 6 weeks after infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice
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• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption
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• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1s homozygotes
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• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection
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• mice succumb more rapidly than controls to 108 CFU of Salmonella with a median survival time of 6 days compared to 8 days for controls
• there is an average 30-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals
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• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality similar to in Slc11a1s homozygotes
• when infected with 105 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
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• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
• when infected with 105 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when infected with Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
• when infected with Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice succumb to 2x1010 CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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