All Phenotypes Slc11a1<r> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc11a1^r
host resistance (Bcg/Ity/Lsh)
MGI:1857756

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc11a1^r/Slc11a1^r	129/Sv	MGI:3036574
hm2	Slc11a1^r/Slc11a1^r	C3H/HeJ-Slc11a1^r	MGI:3036462
ht3	Slc11a1^r/Slc11a1^s	(129/Sv x BALB/c)F1	MGI:2680055
ht4	Slc11a1^s/Slc11a1^r	(129/Sv x C57BL/6J)F1	MGI:3036576
cx5	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	BXH2/TyJ	MGI:3578951
cx6	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r	involves: 129S2/SvPas	MGI:3722760
cx7	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s	involves: 129/Sv * 129S2/SvPas * C57BL/6	MGI:3851240
cx8	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: A/J * BXH2/TyJ	MGI:3578958
cx9	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BALB/cJ * BXH2/TyJ	MGI:3578955
cx10	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BALB/cJ * BXH2/TyJ	MGI:3578956
cx11	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BXH2/TyJ * C3H/HeJ	MGI:3578957
cx12	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BXH2/TyJ * C57BL/6J	MGI:3578953
cx13	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BXH2/TyJ * C57BL/6J	MGI:3578952

Allelic Composition	Slc11a1^r/Slc11a1^r
Genetic Background	129/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:81412 )

• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity

• spleen bacterial loads in mice infected with 10³ Salmonella CFUs increased steadily from day 1 until day 7, then declined sharply by day 21, and were almost undetectable by day 42 postinfection

Allelic Composition	Slc11a1^r/Slc11a1^r
Genetic Background	C3H/HeJ-Slc11a1^r

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:35004 )

• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity

• little or no bacterial proliferation in the spleen at any time following BCG inoculation

Allelic Composition	Slc11a1^r/Slc11a1^s
Genetic Background	(129/Sv x BALB/c)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:28278 )

• little or no bacterial proliferation was observed in the spleen at any time following BCG inoculation

Allelic Composition	Slc11a1^s/Slc11a1^r
Genetic Background	(129/Sv x C57BL/6J)F1

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal susceptibility to bacterial infection ( J:81412 )

• 42 days after IV injection of 10³ Salmonella enteritidis CFUs, spleen CFU levels were intermediate to those in C57BL/6J and 129/Sv

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	BXH2/TyJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^myls mutation (1 available); any Irf8 mutation (35 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

immune system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

decreased interferon-gamma secretion ( J:97931 )

• splenocytes did not secrete IFN-gamma in response to LPS treatment

decreased interleukin-12 secretion ( J:97931 )

• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Allelic Composition	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Flv mutation (2 available); any Casp1 mutation (42 available)
Casp4^del mutation (5 available); any Casp4 mutation (33 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁶ Salmonella typhimurium, mice have a shorter time to death than Slc11a1^r homozygotes

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁶ Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes

• when infected with 10⁶ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes

• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1^r homozygotes

Allelic Composition	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Sesh mutation (5 available); any Casp1 mutation (42 available)
Casp4^del mutation (5 available); any Casp4 mutation (33 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:112400 )

• mice succumb to 2x10¹⁰ CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: A/J * BXH2/TyJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s
Genetic Background	involves: BALB/cJ * BXH2/TyJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: BALB/cJ * BXH2/TyJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: BXH2/TyJ * C3H/HeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:97931 )

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system

enlarged spleen ( J:97931 )

growth/size/body

enlarged spleen ( J:97931 )

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: BXH2/TyJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s
Genetic Background	involves: BXH2/TyJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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