Analysis Tools|
Allele Symbol Allele Name Allele ID |
T+ wild type MGI:1857758 |
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| Summary |
80 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Short and kinked tail in the T11J/T+ mouse
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• the tail can be high set
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• tail length varies from one heterozygote to the next with some having nearly normal tail length and others having almost no tail
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• the tail is often blunt or kinked
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• some heterozygotes have been found to have reduced pelvic size with hip bones closer together than normal
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• some heterozygotes have been found to have no anal opening
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• preweaning mortality is 14% compared with 3% seen in matings of wild-type mice
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• tailless mice of this genotype are not uncommon
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• typically possessing only a short bone-less caudal filament
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born
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• some males are infertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born
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• some males are infertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born
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• some males are infertile
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• fewer than expected (27.1%) of mice are short-tailed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ranging from 1 cm to half of normal tail length
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show varying degrees of tail defects similar heterozygous brachyury (T) mutants
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• observed in some heterozygotes
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• observed in some heterozygotes
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• observed in some heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• few heterozygotes mice of heterozygote females survive birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by E 12, mutants show constriction at the base of the tail
• later in development, the abnormalities observed are less severe and occur more posteriorly than in Tc/tw5 embryos
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• at E12.5, one accessory neural tube is observed
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• unlike T
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• embryos display ventral duplication of the spinal cord
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• at E12.5, one accessory neural tube is observed
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• unlike T
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• some embryos show duplication or intermittent absence of the notochord
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• by E 12, mutants show constriction at the base of the tail
• later in development, the abnormalities observed are less severe and occur more posteriorly than in Tc/tw5 embryos
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• unlike T
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• embryos display partial or complete absence of bony vertebrae posterior to midliver level
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size
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• caudal vertebrae numbers range from 10 to 24, with an average of 21
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• seen by E11
(J:13018)
• tail is reduced by about 1/3 in most mutants
(J:15081)
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• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal
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• contain a notochord, however it can be retained in the roof of the gut or cloaca for varying distances and for a limited period, it may be slow to separate from the overlying neural plate or neural tube, or it may secondarily become incorporated completely into the neural tube or the tail-gut
(J:15081)
• the notocord has a central lumen in places
(J:15081)
• commonly see branching of the notochord proper; at E10-12.5, branches occur mainly in the region of the cloaca and the proximal parts of the tail
(J:15081)
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• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size
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• caudal vertebrae numbers range from 10 to 24, with an average of 21
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• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axial development is disrupted at a more anterior position that in other alleles of this locus
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• extremely short tail; more severe than other alleles at this locus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ratio of mutant to wild-type is less than 1 to 1 at birth
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• 32% of curtailed mice die between birth and weaning
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• while approximately 5% of heterozygotes have a short tail not more than 20% normal length, most have no normal tail but a short boneless caudal filament
(J:5003)
• tail is reduced to a very short curly filament without skeleton and in some instances the tail is altogether absent
(J:64262)
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• often extensive in the thoracic region
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• aside from slight traces in the lower thoracic and lumbar regions, the intervertebral nuclei pulposi are absent at 3 weeks of age
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• the neural arch is partially double in some heterozygotes
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• the axis odontoid process is absent resulting in a horseshoe-shaped articulation between the atlas and axis
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• between the second and third vertebrae
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• the centra of cervical vertebrae are wider than normal, the axis tends to ossify from twin centers, and distortion and fusion is found in some throacic centra
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected carried the T34H allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected carried the T32H allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the transmission ratio distortion associated with t6 is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected carried the T33H allele
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• male fertility is low
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the transmission ratio distortion associated with t6 is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the transmission ratio distortion associated with t6 is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected offsprings carried the th51 allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viability is poor and no males survive into adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• majority of tails are comprised of fewer than 8 vertebrae
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• majority of tails are comprised of fewer than 8 vertebrae
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• lumbar vertebrae defect consisting of an imperfect fusion of the two ventral halves of the vertebra, resulting in an abnormal centrum
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the transmission ratio distortion associated with t6 is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no offsprings carried the T29H allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• high transmission ratio distortion in favour of the thr4 haplotype from males
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when males of this genotype are mated to wild-type females the t-haplotype appears among teh offspring more frequently than expected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most curtailed heterozygotes homozygous for this transgene have normal length tails with blunted ends, but a minority have short tails
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in the presence of T, transgene carriers have normal length tails, indicative of a complete rescue of phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most transgene carriers have a short tail, a partial rescue of the curtailed phenotype, and the tail length varies from one-eighth to three-fourths normal tail length
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• six of seven found to have short tails with the seventh having no tail; this is a partial rescue of the compound heterozygous phenotype in the absence of the transgene wherein sevin out of sevin have a tailless phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• attenuated development of the posterior part of the body
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• generally distorted, duplicated or fused with the mesenchyme
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• presents as a dorsal blood blister in the lumbosacral region
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• E11-12 embryos show abnormalities in the medio-dorsal area
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• seen in E11-12 embryos
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• seen in E11-12 embryos
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• at E10 a constriction occurs as the tail develops
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• generally distorted, duplicated or fused with the mesenchyme
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• presents as a dorsal blood blister in the lumbosacral region
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• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae
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• at E10 a constriction occurs as the tail develops
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• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region
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• presents as a dorsal blood blister in the lumbosacral region
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• rib fusions, lack of vertebral bodies and arches
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• rib fusions, lack of vertebral bodies and arches
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• an abnormality of thoracic and lumbar vertebrae
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• an abnormality of thoracic and lumbar vertebrae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a test cross with a wild-type female mouse the t-haplotype is seen in offspring less frequently than expected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when males of this genotype are mated to wild-type females the t haplotype occurs among the offspring more frequently than expected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males of this genotype transmit tw73 to 88.6 per cent of offspring
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• all mice of this genotype are tailless
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice are dead by 60 days of age; the few longest-lived have hind-limb paralysis
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• most die shortly after birth and have a blood blister in the lumbosacral area and hind-limb paralysis
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• all mice of this genotype are tailless
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| N |
• mice are fertile and there is no evidence of transmission ratio distortion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice with this genotype have short tails; they are not tailless as are mice heterozygous for brachyury and carrying any of the majority of other t haplotypes
• there is no transmission ratio distortion as might be expected from males of this genotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 85% of offspring produced from 3 matings of Tts6 males to wild-type females are short-tailed; 15% are normal-tailed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T-bearing gametes are in excess although not uniformly the case from male to male
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 37% of sperm from males of this genotype carry the tks1 haplotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size
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• the notochord is increased in bulk not only in the distal growth zone (as in T heterozygotes) but in the whole tail, in the cloacal region and even more anteriorly in the lumbar region and has large lumina
• the notochord is present throughout the length of the tail, however it becomes incorporated into the neural tube throughout the tail and often the cloacal region
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• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the tail length is normal although a mouse inheriting a t haplotype with T is frequently tailless
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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