reproductive system
N |
• males exhibit normal transmission ratio
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Allele Symbol Allele Name Allele ID |
t+ wild type MGI:1857759 |
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Summary |
59 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• males exhibit normal transmission ratio
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• male mice exhibit moderately high transmission of th7m2
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• males give low ratio of tlow2H young
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice of this genotype have normal tails although combinations of some other t haplotypes and T produce short-tailed mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected carried the T34H allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the transmission ratio distortion associated with t6 is increased
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected carried the T33H allele
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• male fertility is low
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• viability is poor and no males survive into adulthood
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected offsprings carried the th51 allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected carried the T32H allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the transmission ratio distortion associated with t6 is increased
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the transmission ratio distortion associated with t6 is increased
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit increased transmission of the t-haplotype compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit increased transmission of the t-haplotype compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the deletion in this genotype identifies a locus on haplotype tw73 that causes lethality at birth, tw73lab
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• whether alleles are in cis or trans, mice exhibit reduced transmission of tw18 compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit increased transmission of tw18 compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• reduced transmission found for sperm bearing t6
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• compromised sperm motility is inferred as overexpression of Tagap1 results in greater than normal t6 haplotype transmission
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• reduced transmission found for sperm bearing t6
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• compromised sperm motility is inferred as overexpression of Tagap1 results in greater than normal t6 haplotype transmission
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no offsprings carried the T29H allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the transmission ratio distortion associated with t6 is increased
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice transmitted the th49 allele to only 35% of their offspring compared to a transmission rate of 47% for mice without the Fgd2 mutant allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• high transmission ratio distortion in favour of the thr4 haplotype from males
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• due to a deletion associated with th20, this genotype looks like a mouse homozygous for the recessive mutation tufted
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• when males of this genotype are mated to wild-type females the t-haplotype appears among teh offspring more frequently than expected
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• six of seven found to have short tails with the seventh having no tail; this is a partial rescue of the compound heterozygous phenotype in the absence of the transgene wherein sevin out of sevin have a tailless phenotype
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit reduced transmission of th49 compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit reduced transmission of th49 compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• attenuated development of the posterior part of the body
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• generally distorted, duplicated or fused with the mesenchyme
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• presents as a dorsal blood blister in the lumbosacral region
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• E11-12 embryos show abnormalities in the medio-dorsal area
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• seen in E11-12 embryos
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• seen in E11-12 embryos
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• at E10 a constriction occurs as the tail develops
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• generally distorted, duplicated or fused with the mesenchyme
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• presents as a dorsal blood blister in the lumbosacral region
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• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae
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• at E10 a constriction occurs as the tail develops
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• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region
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• presents as a dorsal blood blister in the lumbosacral region
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• rib fusions, lack of vertebral bodies and arches
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• rib fusions, lack of vertebral bodies and arches
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• an abnormality of thoracic and lumbar vertebrae
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• an abnormality of thoracic and lumbar vertebrae
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in a test cross with a wild-type female mouse the t-haplotype is seen in offspring less frequently than expected
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• when males of this genotype are mated to wild-type females the t haplotype occurs among the offspring more frequently than expected
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• males of this genotype transmit tw73 to 88.6 per cent of offspring
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• all mice of this genotype are tailless
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• all mice are dead by 60 days of age; the few longest-lived have hind-limb paralysis
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• most die shortly after birth and have a blood blister in the lumbosacral area and hind-limb paralysis
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• all mice of this genotype are tailless
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N |
• mice are fertile and there is no evidence of transmission ratio distortion
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• the tail length is normal although a mouse inheriting a t haplotype with T is frequently tailless
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice with this genotype have short tails; they are not tailless as are mice heterozygous for brachyury and carrying any of the majority of other t haplotypes
• there is no transmission ratio distortion as might be expected from males of this genotype
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 85% of offspring produced from 3 matings of Tts6 males to wild-type females are short-tailed; 15% are normal-tailed
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size
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• the notochord is increased in bulk not only in the distal growth zone (as in T heterozygotes) but in the whole tail, in the cloacal region and even more anteriorly in the lumbar region and has large lumina
• the notochord is present throughout the length of the tail, however it becomes incorporated into the neural tube throughout the tail and often the cloacal region
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• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• T-bearing gametes are in excess although not uniformly the case from male to male
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only 37% of sperm from males of this genotype carry the tks1 haplotype
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the transmission ratio distortion associated with t6 is decreased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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