Phenotypes associated with this allele

• Allele Symbol: T^Wis
• Allele Name: brachyury Wisconsin
• Allele ID: MGI:1857760
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	T^Wis/T^Wis	involves: A/J	MGI:3844474
hm2	T^Wis/T^Wis	Not Specified	MGI:2169517
ht3	T^Wis/T^+	involves: A/J	MGI:3844471
ht4	T^Wis/T^+	Not Specified	MGI:2169528

Genotype
MGI:3844474

hm1

• Allelic Composition: T^Wis/T^Wis
• Genetic Background: involves: A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality ( J:9032 )

Genotype
MGI:2169517

hm2

• Allelic Composition: T^Wis/T^Wis
• Genetic Background: Not Specified

nervous system

abnormal spinal cord morphology ( J:16412 )

• grossly abnormal shape at E9.5

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:16412 , J:78124 )

embryo

abnormal mesoderm development ( J:16412 )

• mesoderm formation is arrested at E9.5

abnormal axial mesoderm morphology ( J:78124 )

• formation is disrupted

abnormal notochord morphology ( J:78124 )

• at E8 extension of the notochord precursor is disrupted

abnormal prechordal plate morphology ( J:16412 )

• notochordal plate cells are not positioned correctly ant the ventral side of the hindbrain

abnormal posterior primitive streak morphology ( J:16412 )

• disorganized, appearing as a bulk of densely packed cells

absent primitive node ( J:16412 )

abnormal primitive streak formation ( J:16412 , J:78124 )

absent somites ( J:16412 )

• somites are missing in a position where the lateral plate is present

absent allantois ( J:78124 )

Genotype
MGI:3844471

ht3

• Allelic Composition: T^Wis/T⁺
• Genetic Background: involves: A/J

limbs/digits/tail

absent tail ( J:9032 )

Genotype
MGI:2169528

ht4

• Allelic Composition: T^Wis/T⁺
• Genetic Background: Not Specified

embryo

abnormal rostral-caudal axis patterning ( J:16412 )

• axial development is disrupted at a more anterior position that in other alleles of this locus

abnormal neural tube morphology ( J:16412 )

incomplete caudal neuropore closure ( J:16412 )

absent notochord ( J:16412 )

abnormal tail bud morphology ( J:16412 )

skeleton

decreased rib number ( J:16412 )

abnormal sacral vertebrae morphology ( J:16412 )

fusion of vertebral arches ( J:16412 )

abnormal vertebral body morphology ( J:16412 )

absent vertebral body ( J:16412 )

nervous system

abnormal neural tube morphology ( J:16412 )

incomplete caudal neuropore closure ( J:16412 )

limbs/digits/tail

abnormal tail bud morphology ( J:16412 )

short tail ( J:16412 )

• extremely short tail; more severe than other alleles at this locus

thin tail ( J:16412 )