Phenotypes associated with this allele

• Allele Symbol: Ikbkb^tm1Trk
• Allele Name: targeted mutation 1, Tularik Inc
• Allele ID: MGI:1857761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkb^tm1Trk/Ikbkb^tm1Trk	involves: 129S1/Sv * C57BL/6	MGI:2179404

Genotype
MGI:2179404

hm1

• Allelic Composition: Ikbkb^tm1Trk/Ikbkb^tm1Trk
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:55680 )

• homozygotes die at ~E14.5, apparently due to severe liver degeneration

liver/biliary system

increased hepatocyte apoptosis ( J:55680 )

• at E14.5, homozygotes exhibit significantly increased hepatocyte apoptosis

abnormal hepatocyte morphology ( J:55680 )

• at E14.5, mutant hepatocytes display pyknotic nuclei

liver degeneration ( J:55680 )

• at E14.5, homozygotes exhibit massive liver degeneration; however, fetal liver hematopoiesis remains unaffected

cellular

abnormal cell physiology ( J:55680 )

• mutant MEFs obtained from E12.5 homozygotes show reduced basal NF-kappaB activity and impaired NF-kappaB activation upon induction with TNF or IL-1beta

increased fibroblast apoptosis ( J:55680 )

• in the presence of cycloheximide, mutant MEFs show a 30-fold increase in sensitivity to TNF-induced apoptosis relative to wild-type MEFs

increased hepatocyte apoptosis ( J:55680 )

• at E14.5, homozygotes exhibit significantly increased hepatocyte apoptosis