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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam2tm1Dgm
targeted mutation 1, Diana G Myles
MGI:1857764
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam2tm1Dgm/Adam2tm1Dgm involves: 129P2/OlaHsd * C57BL/6N MGI:2654752
cx2
 		Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf 		involves: C57BL/6N MGI:3039874


Genotype
MGI:2654752
hm1
Allelic
Composition		 Adam2tm1Dgm/Adam2tm1Dgm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:50040 )
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal
reduced male fertility ( J:50040 )
• fertility rate is 2% compared to wild-type
impaired fertilization ( J:50040 )
• the ability of sperm from mutant mice to bind to and fuse with the egg plasma membrane is reduced
• once fused, egg activation proceeds normally
impaired binding of sperm to zona pellucida ( J:50040 )
• sperm are unable to adhere to the zona pellucida

cellular
impaired sperm migration in female genital tract ( J:50040 )
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal




Genotype
MGI:3039874
cx2
Allelic
Composition		 Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
Adam3tm1Pmkf mutation (1 available); any Adam3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:69282 )
• the ability of sperm from mutant mice to bind to and fuse with eggs is reduced to the same extent as in either single knock out mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory