Phenotypes associated with this allele

• Allele Symbol: Ikbkb^tm1Mka
• Allele Name: targeted mutation 1, Michael Karin
• Allele ID: MGI:1857769
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkb^tm1Mka/Ikbkb^tm1Mka	involves: 129S6/SvEvTac * C57BL/6	MGI:2179398

Genotype
MGI:2179398

hm1

• Allelic Composition: Ikbkb^tm1Mka/Ikbkb^tm1Mka
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Anemic appearance of E13.5 Ikbkb^tm1Mka/Ikbkb^tm1Mka mutants

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:55737 )

• dead by E13.5

liver/biliary system

abnormal hepatocyte morphology ( J:55737 )

• no viable hepatocytes were detected at E13.5 and the numbers of dead cells with highly condensed and fragmented nuclei were markedly increased

liver degeneration ( J:55737 )

• degeneration of the liver is seen at E13.5, however limbs and head developed normally