Phenotypes associated with this allele

• Allele Symbol: Foxg1^tm1M
• Allele Name: targeted mutation 1, Memorial Sloan Kettering Cancer Center
• Allele ID: MGI:1857771
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxg1^tm1M/Foxg1^tm1M	involves: 129S1/Sv	MGI:4431391
hm2	Foxg1^tm1M/Foxg1^tm1M	involves: 129S1/Sv * C57BL/6J	MGI:2175027
ht3	Foxg1^tm1M/Foxg1^+	involves: C57BL/6 * CBA	MGI:3767192
cn4	Fgf8^tm1.1Mrt/Fgf8^tm1.4Mrt Foxg1^tm1M/Foxg1^+	involves: 129P2/OlaHsd	MGI:3654832
cx5	Foxg1^tm1(tTA)Lai/Foxg1^tm1M Tg(tetO-Foxg1)1Lai/0	involves: 129S1/Sv * C57BL/6	MGI:2451132

Genotype
MGI:4431391

hm1

• Allelic Composition: Foxg1^tm1M/Foxg1^tm1M
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neuronal precursor proliferation ( J:78115 )

• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

abnormal telencephalon morphology ( J:78115 )

• dorsal telencephalon is small

abnormal neocortex morphology ( J:78115 )

• neocortex has an irregular contour

embryo

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

cellular

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neuronal precursor proliferation ( J:78115 )

• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice

Genotype
MGI:2175027

hm2

• Allelic Composition: Foxg1^tm1M/Foxg1^tm1M
• Genetic Background: involves: 129S1/Sv * C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:26720 )

• all homozygotes are born alive but die within 20 minutes after birth

respiratory system

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

respiratory distress ( J:26720 )

• all newborn homozygotes make intermittent gasping motions

respiratory failure ( J:26720 )

• at autopsy, respiratory alveoli appear uninflated, indicating respiratory failure

nervous system

abnormal telencephalon morphology ( J:26720 )

• at E12.5, the dorsal telencephalon is reduced in size whereas the ventral telencephalon is nearly absent

abnormal telencephalon development ( J:26720 )

• development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon

• proliferation of ventral telencephalic neuroepithelium is reduced progressivley such that growth stops at E10.5

• abnormal proliferation of dorsal telencephalic neuroepithelium becomes more severe as development proceeds

• at E12.5, dorsal telencephalic vesicles are positioned more ventrally and closer to the level of the eyes

small embryonic telencephalon ( J:26720 )

• by E10.5, mutant brains exhibit significantly smaller telencephalic vesicles; this size difference is pronounced at E12.5

abnormal cerebral hemisphere morphology ( J:26720 )

• newborn homozygotes exhibit a 95% mass reduction of the cerebral hemispheres which rest on the dorsolateral surface of the diencephalon

abnormal cerebral cortex morphology ( J:26720 )

• at E12.5, mutant brains display an uneven cerebral cortex due to buckling of the neuroepithelium and to variations in cortical tissue thickness

small olfactory bulb ( J:26720 )

• mutant olfactory bulbs are significantly smaller than wild-type

abnormal embryonic/fetal subventricular zone morphology ( J:26720 )

• at E12.5, mutant ganglionic eminences are replaced by a thin neuroepithelium

craniofacial

abnormal cranium morphology ( J:26720 )

• newborn homozygotes display flattening of the frontal skull

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

vision/eye

abnormal eye morphology ( J:26720 )

• newborn homozygotes display ellipsoid instead of round eyes

• ventral rotation of the entire eye is observed at E12.5

abnormal retina morphology ( J:26720 )

• newborn homozygotes display an irregular retinal contour, that is pronounced in the nasal retina

abnormal retina neuronal layer morphology ( J:26720 )

• at E12.5, mutant eyes display a wavy anterior retinal neuroepithelium

homeostasis/metabolism

cyanosis ( J:26720 )

• all newborn homozygotes appear cyanotic

behavior/neurological

no spontaneous movement ( J:26720 )

• newborn homozygotes are flaccid and exhibit minimal spontaneous movement

skeleton

abnormal cranium morphology ( J:26720 )

• newborn homozygotes display flattening of the frontal skull

taste/olfaction

abnormal nasal placode morphology ( J:26720 )

• mutant nasal placodes fail to grow normally after E9.5

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

growth/size/body

abnormal olfactory epithelium morphology ( J:26720 )

• mutant nasal epithelium fails to grow normally after E9.5

Genotype
MGI:3767192

ht3

• Allelic Composition: Foxg1^tm1M/Foxg1⁺
• Genetic Background: involves: C57BL/6 * CBA

nervous system

abnormal brain morphology ( J:128207 )

• reduction in dimensions of cerebral hemispheres is observed by postnatal day 4

Genotype
MGI:3654832

cn4

• Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.4Mrt; Foxg1^tm1M/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal neuron apoptosis ( J:111586 )

• at E10.5 in the telencephalic midline, extent of apoptosis in Foxg1 hypomorphs resembles wild-type more than Fgf8^tm1.1Mrt/Fgf8^tm1.4Mrt hypomorphs

cellular

abnormal neuron apoptosis ( J:111586 )

• at E10.5 in the telencephalic midline, extent of apoptosis in Foxg1 hypomorphs resembles wild-type more than Fgf8^tm1.1Mrt/Fgf8^tm1.4Mrt hypomorphs

Genotype
MGI:2451132

cx5

• Allelic Composition: Foxg1^tm1(tTA)Lai/Foxg1^tm1M; Tg(tetO-Foxg1)1Lai/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

nervous system

nervous system phenotype ( J:78115 )

N • size of the neocortex and proliferation of progenitor cells throughout the dorsal telencephalon are restored to normal levels by expression of the mutant protein

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

abnormal basal ganglion morphology ( J:78115 )

• absent

abnormal telencephalon morphology ( J:78115 )

• dorsomedial telencephalon is abnormal

embryo

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

cellular

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle