Analysis Tools|
Allele Symbol Allele Name Allele ID |
Adcy1tm1Drs targeted mutation 1, Daniel R Storm MGI:1857775 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in mutants this allodynia is significantly reduced in Adcy1tm1Drs
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• phase 2 responses to formalin injection are decreased in mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locus coeruleus neurons exhibit normal firing in response to chronic morphine treatment and withdrawal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a transfer test in the Morris water task, mutants show no preference for the quadrant where the platform had been located while wild-type mice spent increase time in that quadrant and crossed the target area more frequently
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• the rate of increase of the EPSP slope for mutants is half that of controls after tetanic stimulation; maximal EPSP slope above baseline is reduced by 40% in mutants
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• adenylyl cyclase 1 activity is reduced 63% in the cerebellum, 38% in the neocortex and 46% in the hippocampus of mutant mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished
• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type
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• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts
• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double knockout animals exhibit passive avoidance learning but display a memory deficit as early as 30 minutes after training; lower latencies are also apparent 24 hours and 8 days after training compared with single knockouts or wild-type; latencies are comparable to controls after forskolin treatment of CA1 of the hippocampus15 minutes before training
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• double knockouts exhibit a decrease in freezing behavior compared to wild-type after 8 days in a contextual learning paradigm
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• sustained L-LTP could not be generated in hippocampal slices from double knockout mice; the fEPSP slope exhibited a significant decrement at all times after tetanus; LTP dropped off after 80 minutes compared to 3 hours in each of the single knockouts
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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