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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Morc1Tg(Tyr)1Az
transgene insertion 1, Andrew R Zinn
MGI:1857787
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az FVB/NHsd-Morc1Tg(Tyr)1Az MGI:2384276
hm2
 		Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az involves: C57BL/6N * FVB/N MGI:5766068


Genotype
MGI:2384276
hm1
Allelic
Composition		 Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic
Background		 FVB/NHsd-Morc1Tg(Tyr)1Az
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morc1Tg(Tyr)1Az mutation (1 available); any Morc1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased male germ cell number ( J:51211 )
• neither secondary spermatocytes nor spermatids detectable in homozygotes
arrest of male meiosis ( J:51211 )
• spermatogenesis arrested prior to the pachytene stage of meiotic prophase I
abnormal apoptosis ( J:51211 )
• apoptotic testicular cells

endocrine/exocrine glands
small testis ( J:51211 )
• less than one third normal size, on average

reproductive system
decreased male germ cell number ( J:51211 )
• neither secondary spermatocytes nor spermatids detectable in homozygotes
arrest of male meiosis ( J:51211 )
• spermatogenesis arrested prior to the pachytene stage of meiotic prophase I
small testis ( J:51211 )
• less than one third normal size, on average
male infertility ( J:51211 )
• males are infertile, however females exhibit histologically normal ovaries and are fertile




Genotype
MGI:5766068
hm2
Allelic
Composition		 Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic
Background		 involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morc1Tg(Tyr)1Az mutation (1 available); any Morc1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:227356 )
N
• females show normal vertical and horizontal locomotor activity and unaltered anxiety-related behavior
abnormal depression-related behavior ( J:227356 )
• females exhibit a lower latency to float on day 1 of the forced swim test and an increase in immobility on day 1 and 2 of the forced swim test
• in the learned helplessness paradigm of depression, females show more failures to escape and a tendency of increased latency to escape

endocrine/exocrine glands

reproductive system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
melancholic depression DOID:1595 OMIM:608516
 J:227356




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory