Analysis Tools
normal phenotype
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• homozygotes are viable, fertile, and show no obvious behavioral abnormalities
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Allele Symbol Allele Name Allele ID |
Gli1tm1Alj targeted mutation 1, Alexandra L Joyner MGI:1857797 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are viable, fertile, and show no obvious behavioral abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mutants are recovered after E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected double homozygotes are seen at E18.5
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• no double homozygotes survive past birth
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• at E12.5, pituitary gland is absent
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• dorsal and ventral regions of the telencephalon appeared abnormal
• neural epithelium is thickened in telencephalic region
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• motor neurons are induced in the ventral midline of the spinal cord, similar to Gli2 single homozygotes
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• at E12.5, pituitary gland is absent
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• at E12.5, the 2 lobes are similar in size and planar
• at E12.5 and 18.5, only one very small lobe is present bilaterally; however, branching is visible in the lobes
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• at E15.5 and 18.5 all four limbs had five digits; however an extra postaxial stub of a digit is present
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5 and E18.5, lungs appear to have 2 small lobes
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• at E12.5 and E18.5, lungs appear smaller than normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die shortly after birth with only 3.8% surviving to weaning age
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• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
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• at E12.5 and 14, notochord has not regressed from the ventral spinal cord
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• animals which survive to weaning are smaller
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• animals unable to right themselves
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• hopping gait
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• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
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• motor neurons are located closer to the midline than normal
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• at E18.5, the left lobe is reduced in width
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• at E12.5, slight reduction in size of accessory lobe visible
• at E18.5, the accessory lobe is reduced in length and in width
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• at E18.5, the right cranial lobe is reduced in length
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• external genitalia are incompletely developed
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• at 5-7 weeks of age the gut is distended
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• phenotype is similar to Tg(Shh)#Dje mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygous mice survive to at least 3 months of age and appear normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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