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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gli1tm1Alj
targeted mutation 1, Alexandra L Joyner
MGI:1857797
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gli1tm1Alj/Gli1tm1Alj involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2176901
cn2
Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550093
cx3
Gli1tm1Alj/Gli1tm1Alj
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster MGI:3795858
cx4
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3579187
cx5
Gli1tm1Alj/Gli1tm1Alj
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3614422
cx6
Gli1tm1Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3614423
cx7
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3579188
cx8
Gli1tm1Alj/Gli1tm1Alj
Tg(Shh)#Dje/0
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster MGI:3665551
cx9
Gli1tm1Alj/Gli1tm1Alj
Glis1tm1Mnks/Glis1tm1Mnks
mixed MGI:3615812


Genotype
MGI:2176901
hm1
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are viable, fertile, and show no obvious behavioral abnormalities




Genotype
MGI:5550093
cn2
Allelic
Composition
Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• hindlimb polydactytly




Genotype
MGI:3795858
cx3
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Ptch1tm1Mps/Ptch1tm1Mps
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mutants are recovered after E9.5




Genotype
MGI:3579187
cx4
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2tm1Alj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Gli2tm1Alj mutation (0 available); any Gli2 mutation (169 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no double homozygotes survive past birth
• fewer than expected double homozygotes are seen at E18.5

nervous system
• at E12.5, pituitary gland is absent
• dorsal and ventral regions of the telencephalon appeared abnormal
• neural epithelium is thickened in telencephalic region
• motor neurons are induced in the ventral midline of the spinal cord, similar to Gli2 single homozygotes

endocrine/exocrine glands
• at E12.5, pituitary gland is absent

respiratory system
• at E12.5, the 2 lobes are similar in size and planar
• at E12.5 and 18.5, only one very small lobe is present bilaterally; however, branching is visible in the lobes

limbs/digits/tail
• at E15.5 and 18.5 all four limbs had five digits; however an extra postaxial stub of a digit is present




Genotype
MGI:3614422
cx5
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Gli3Xt-J/Gli3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Gli3Xt-J mutation (3 available); any Gli3 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail




Genotype
MGI:3614423
cx6
Allelic
Composition
Gli1tm1Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Gli2tm1Alj mutation (0 available); any Gli2 mutation (169 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• at E12.5 and E18.5, lungs appear to have 2 small lobes
• at E12.5 and E18.5, lungs appear smaller than normal




Genotype
MGI:3579188
cx7
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Gli2tm1Alj mutation (0 available); any Gli2 mutation (169 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die shortly after birth with only 3.8% surviving to weaning age

embryo
• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
• at E12.5 and 14, notochord has not regressed from the ventral spinal cord

growth/size/body
• animals which survive to weaning are smaller

endocrine/exocrine glands

behavior/neurological
• animals unable to right themselves
• hopping gait

nervous system
• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
• motor neurons are located closer to the midline than normal

respiratory system
• at E18.5, the left lobe is reduced in width
• at E12.5, slight reduction in size of accessory lobe visible
• at E18.5, the accessory lobe is reduced in length and in width
• at E18.5, the right cranial lobe is reduced in length

reproductive system
• external genitalia are incompletely developed

digestive/alimentary system
• at 5-7 weeks of age the gut is distended




Genotype
MGI:3665551
cx8
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Tg(Shh)#Dje/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Tg(Shh)#Dje mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3615812
cx9
Allelic
Composition
Gli1tm1Alj/Gli1tm1Alj
Glis1tm1Mnks/Glis1tm1Mnks
Genetic
Background
mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Glis1tm1Mnks mutation (0 available); any Glis1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• double homozygous mice survive to at least 3 months of age and appear normal





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory