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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rbl1tm1Mru
targeted mutation 1, Michael Rudnicki
MGI:1857798
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rbl1tm1Mru/Rbl1tm1Mru involves: 129S4/SvJae * BALB/c MGI:4353992
hm2
Rbl1tm1Mru/Rbl1tm1Mru involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:4353989
hm3
Rbl1tm1Mru/Rbl1tm1Mru involves: 129S4/SvJae * BALB/cJ MGI:4353911
hm4
Rbl1tm1Mru/Rbl1tm1Mru involves: 129S4/SvJae * BALB/cJ * C57BL/6J MGI:4353912
cx5
Rb1tm1Tyj/Rb1tm1Tyj
Rbl1tm1Mru/Rbl1tm1Mru
involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6 MGI:4353990


Genotype
MGI:4353992
hm1
Allelic
Composition
Rbl1tm1Mru/Rbl1tm1Mru
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation (0 available); any Rbl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% of mice die by 3 weeks of age

adipose tissue
• in testicular and ovarian white adipose tissue fat pad
• in white adipose tissue fat pad
• in white adipose tissue fat pad
• interscapular, inguinal, testicular, ovarian, and intraperitoneal white adipose fat pads are reduced in weight compared to in wild-type mice
• however, interscapular brown adipose tissue depots are normal
• white adipose tissue resembles brown adipose tissue with small-sized, unilocular adipocytes with many multilocular appearing cells unlike in wild-type mice
• white adipose tissue differentiation of preadipocytes is deficient in vivo
• however, in vitro preadipocyte differentiation is normal
• neonates and adults exhibit decreased white adipose tissue mass compared to in wild-type mice despite normal suckling, food intake, and nutrient absorption
• mice lack white adipose tissue in the interscapular and inguinal depots and have smaller than normal testicular and ovarian depots

growth/size/body
• at P5, mice are runted despite normal suckling

liver/biliary system
• at P5, the liver is yellow in appearance due to excessive lipid accumulation unlike in wild-type mice
• however, after weaning liver lipid content is normal

homeostasis/metabolism
• 12% higher than in wild-type mice




Genotype
MGI:4353989
hm2
Allelic
Composition
Rbl1tm1Mru/Rbl1tm1Mru
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation (0 available); any Rbl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit an increase in the rate of progenitor regeneration
• however, neurogenesis in the olfactory bulb is normal
• more proliferating cells are found in the ventricular subependyma than in wild-type mice
• the number of apoptotic cells in the ventricular subependyma is increased compared to in wild-type mice
• mice exhibit increased neuronal precursor numbers due to increased proliferation
• cultured E10 telencephalic neuroepithelia produces more primary neurospheres than cultures from wild-type mice
• adult brain cultures produce 2-fold more primary neurospheres than cultures from wild-type mice independent of cell density
• mice exhibit a higher number of slowly dividing neural precursor cells compared to in wild-type mice

cellular
• mice exhibit an increase in the rate of progenitor regeneration
• however, neurogenesis in the olfactory bulb is normal




Genotype
MGI:4353911
hm3
Allelic
Composition
Rbl1tm1Mru/Rbl1tm1Mru
Genetic
Background
involves: 129S4/SvJae * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation (0 available); any Rbl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 2 and 4 months, 10% of mice die unlike wild-type mice

hematopoietic system
• sites of extramedullary hematopoiesis exhibit hyperplasia rather than neoplasia
• mice develop a diathetic myeloproliferative disorder
• the number of mice exhibiting abnormal hematopoiesis increases with age
• the number of colony forming units of granulocyte-macrophages that form from femur marrow is increased 2.7- to 12-fold compared to in wild-type samples
• extramedullary hematopoiesis is present in the spleen and liver with some mice exhibiting extramedullary hematopoiesis in the thymus, pancreas, kidneys, and skeletal muscles
• with a strong shift to myeloid lineages
• myeloid extramedullary hematopoiesis is present in the red pulp

growth/size/body
• all mice are runted
• Background Sensitivity: runting is more severe on a background involving 129S4/SvJae and BALB/cJ than on one involving 129S4/SvJae, BALB/cJ, and C57BL/6J
• by 3 weeks of age mice weight half as much as wild-type mice
• by 12 weeks, mice weigh 80% of wild-type
• however, by 15 months mice have a normal weight
• mice exhibit postnatal growth retardation
• however, mice exhibit normal postnatal development

cellular
• proliferation of adult myoblast in culture is increased compared to that of wild-type myoblasts with a shift from G1 to S phase and an 8-fold reduction in spontaneous differentiation
• mouse embryonic fibroblasts from E13.5 embryos exhibit increased proliferation doubling every 35 hours compared with wild-type cells that double every 60 hours

immune system
• myeloid extramedullary hematopoiesis is present in the red pulp
• at 10 months, 70% of mice exhibit evidence of acute or chronic inflammation unlike wild-type mice

muscle
• proliferation of adult myoblast is increased compared to that of wild-type myoblasts with a shift from G1 to S phase and an 8-fold reduction in spontaneous differentiation

integument
• skin ulcers and abscesses




Genotype
MGI:4353912
hm4
Allelic
Composition
Rbl1tm1Mru/Rbl1tm1Mru
Genetic
Background
involves: 129S4/SvJae * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation (0 available); any Rbl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• Background Sensitivity: after 2 generations of crosses involving 129S4/SvJae, BALB/cJ, and C57BL/6J, fewer mice appear runted than on a background involving 129S4/SvJae and BALB/cJ




Genotype
MGI:4353990
cx5
Allelic
Composition
Rb1tm1Tyj/Rb1tm1Tyj
Rbl1tm1Mru/Rbl1tm1Mru
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation (5 available); any Rb1 mutation (111 available)
Rbl1tm1Mru mutation (0 available); any Rbl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit increased neuronal precursor numbers due to increased proliferation
• cultured E10 telencephalic neuroepithelia produces more primary neurospheres than cultures from wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory