Analysis Tools
immune system
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• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity
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Allele Symbol Allele Name Allele ID |
Emv30b endogenous ecotropic murine leukemia virus, absent MGI:1857806 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls
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• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice homozygous for the scid mutation do not develop insulitis despite the NOD background and pro-diabetic transgenes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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