Phenotypes associated with this allele

• Allele Symbol: Emv30^b
• Allele Name: endogenous ecotropic murine leukemia virus, absent
• Allele ID: MGI:1857806
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	B2m^tm1Unc/B2m^tm1Unc Emv30^b/Emv30^b Prkdc^scid/Prkdc^scid Tg(B2M)55Hpl/? Mcph1^Tg(HLA-A2.1)1Enge/?	NOD.Cg-B2m^tm1Unc Mcph1^Tg(HLA-A2.1)1Enge Emv30^b Prkdc^scid Tg(B2M)55Hpl/Dvs	MGI:5707036
cx2	Emv30^b/Emv30^b Prkdc^scid/Prkdc^scid	NOD.Cg-Emv30^b Prkdc^scid/Dvs	MGI:3796629
cx3	Emv30^b/Emv30^b Prkdc^scid/Prkdc^scid Tg(IghH280)48Dvs/? Tg(IgkH280)934Dvs/?	NOD.Cg-Emv30^b Prkdc^scid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs	MGI:6303746

Genotype
MGI:5707036

cx1

• Allelic Composition: B2m^tm1Unc/B2m^tm1Unc; Emv30^b/Emv30^b; Prkdc^scid/Prkdc^scid; Tg(B2M)55Hpl/?; Mcph1^{Tg(HLA-A2.1)1Enge}/?
• Genetic Background: NOD.Cg-B2m^tm1Unc Mcph1^{Tg(HLA-A2.1)1Enge} Emv30^b Prkdc^scid Tg(B2M)55Hpl/Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:109851 )

• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity

Genotype
MGI:3796629

cx2

• Allelic Composition: Emv30^b/Emv30^b; Prkdc^scid/Prkdc^scid
• Genetic Background: NOD.Cg-Emv30^b Prkdc^scid/Dvs

neoplasm

increased T cell derived lymphoma incidence ( J:29951 )

• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:29951 )

• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls

hematopoietic system

increased T cell derived lymphoma incidence ( J:29951 )

• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls

immune system

increased T cell derived lymphoma incidence ( J:29951 )

• Background Sensitivity: although thymic lymphomas still initiate in the absence of EMV30, their rate of progression is much less than in the presence of the EMV30 allele with the frequency of thymic lymphomas weighing between 170mg and 910mg at 25 weeks of age is only 20.8% compared to 76.2% in EMV30 homozygous controls

Genotype
MGI:6303746

cx3

• Allelic Composition: Emv30^b/Emv30^b; Prkdc^scid/Prkdc^scid; Tg(IghH280)48Dvs/?; Tg(IgkH280)934Dvs/?
• Genetic Background: NOD.Cg-Emv30^b Prkdc^scid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:274578 )

N • mice homozygous for the scid mutation do not develop insulitis despite the NOD background and pro-diabetic transgenes