Phenotypes associated with this allele

• Allele Symbol: Scp2^tm1Usee
• Allele Name: targeted mutation 1, Udo Seedorf
• Allele ID: MGI:1857809
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scp2^tm1Usee/Scp2^tm1Usee	involves: 129P2/OlaHsd * C57BL/6	MGI:3038005

Genotype
MGI:3038005

hm1

• Allelic Composition: Scp2^tm1Usee/Scp2^tm1Usee
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food intake ( J:47280 )

• food intake is increased considerably in spite of a normal body weight

growth/size/body

growth/size/body region phenotype ( J:47280 )

N • body weight normal

homeostasis/metabolism

abnormal lipid level ( J:47280 )

abnormal circulating cholesterol level ( J:73460 )

increased circulating HDL cholesterol level ( J:73460 )

• levels higher than in controls and drop less on a lithogenic diet

increased circulating LDL cholesterol level ( J:73460 )

• increases on a lithogenic diet but less than in control mice

increased circulating VLDL cholesterol level ( J:73460 )

• increases on a lithogenic diet but less than in control mice

decreased circulating free fatty acids level ( J:47280 )

• circulating levels are slightly decreased

increased circulating triglyceride level ( J:47280 )

• circulating levels are slightly elevated

abnormal bile salt level ( J:73460 )

• bile salt levels lower than normal and increase on a lithogenic diet than in controls

decreased liver cholesterol level ( J:47280 , J:73460 )

• hepatic cholesterol ester levels are depleted (J:47280)

• increased hepatic cholesterol resulting from a lithogenic diet is less than in controls (J:73460)

increased fatty acids level ( J:47280 )

• phytanic acid levels are about 10X normal

decreased liver triglyceride level ( J:47280 )

• hepatic triglyceride storage pools are depleted

liver/biliary system

decreased liver cholesterol level ( J:47280 , J:73460 )

• hepatic cholesterol ester levels are depleted (J:47280)

• increased hepatic cholesterol resulting from a lithogenic diet is less than in controls (J:73460)

decreased liver triglyceride level ( J:47280 )

• hepatic triglyceride storage pools are depleted

abnormal bile secretion ( J:73460 )

• biliary secretion of cholesterol due to a lithogenic diet less than in control mice