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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pla2g2aMom1-r
modifier of Min1, tumor resistance
MGI:1857820
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
ApcMin/Apc+
Pla2g2aMom1-r/Pla2g2a+
either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1 MGI:5529263
cx2
ApcMin/Apc+
Pla2g2aMom1-r/?
Prkdcdxnph/Prkdcdxnph
involves: BALB/cByJ * C57BL/6 MGI:4461429


Genotype
MGI:5529263
cx1
Allelic
Composition
ApcMin/Apc+
Pla2g2aMom1-r/Pla2g2a+
Genetic
Background
either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Pla2g2aMom1-r mutation (0 available); any Pla2g2a mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• controlled for age of the mice, the mean tumor incidence was 5.8 +/- 4.3 compared with 28.5 +/-7.9 in mice with a C57BL/6J background
• mice homozygous for Pla2g2aMom1-r from AKR/J produced by backcrossing the F1 to AKR/J produced offspring with a lower mean tumor incidence of 1.7 +/- 1.7
• mice heterozygous for Pla2g2aMom1-r from C57BL/6J and AKR/J produced by backcrossing the F1 to C57BL/6J show a mean tumor incidence significantly lower than seen in mice having a C57BL/6J background but significantly higher than mice homozygous for Pla2g2a from AKR/J
• inbred srains MA/MyJ and CAST/Ei also carry the tumor suppressing allele Pla2g2aMom1-r s
• inbred strains AKR/J, MA/MyJ, and CAST/Ei are homozygous for the tumor suppressing allele Pla2g2a

digestive/alimentary system
• controlled for age of the mice, the mean tumor incidence was 5.8 +/- 4.3 compared with 28.5 +/-7.9 in mice with a C57BL/6J background
• mice homozygous for Pla2g2aMom1-r from AKR/J produced by backcrossing the F1 to AKR/J produced offspring with a lower mean tumor incidence of 1.7 +/- 1.7
• mice heterozygous for Pla2g2aMom1-r from C57BL/6J and AKR/J produced by backcrossing the F1 to C57BL/6J show a mean tumor incidence significantly lower than seen in mice having a C57BL/6J background but significantly higher than mice homozygous for Pla2g2a from AKR/J
• inbred srains MA/MyJ and CAST/Ei also carry the tumor suppressing allele Pla2g2aMom1-r s
• inbred strains AKR/J, MA/MyJ, and CAST/Ei are homozygous for the tumor suppressing allele Pla2g2a




Genotype
MGI:4461429
cx2
Allelic
Composition
ApcMin/Apc+
Pla2g2aMom1-r/?
Prkdcdxnph/Prkdcdxnph
Genetic
Background
involves: BALB/cByJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Pla2g2aMom1-r mutation (0 available); any Pla2g2a mutation (7 available)
Prkdcdxnph mutation (0 available); any Prkdc mutation (417 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice show 2-3 fold increase in adenoma incidence in the small intestine after X-irradiation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory