All Phenotypes Rxrb<tm1Ipc> MGI Mouse

perinatal lethality, incomplete penetrance ( J:30560 )

• Mendelian ratios at P1 and E18.5 suggest that some animals die in the perinatal period

prenatal lethality, incomplete penetrance ( J:30560 )

• skewed Mendelian ratios at E18.5 suggest that some embryos die during embryonic stages

teratozoospermia ( J:30560 )

abnormal sperm mitochondrial sheath morphology ( J:30560 )

• failure of the mitochondria to arrange helicoidally around the axoneme

coiled sperm flagellum ( J:30560 )

• coiling of the spermatozoon tail was noted in some cases

abnormal acrosome morphology ( J:30560 )

• indented acrosomes, partially detached acrosomes from the nuclear envelope, or absent acrosomes were sometimes observed

absent acrosome ( J:30560 )

• absent acrosome in some cases

detached acrosome ( J:30560 )

• acrosome is partially detached from the nuclear envelope in some cases

decreased germ cell number ( J:30560 )

• variable degrees of germ cell loss were observed in 8-10 month old mice

oligozoospermia ( J:30560 )

asthenozoospermia ( J:30560 )

• impaired sperm motility

abnormal seminiferous tubule morphology ( J:30560 )

• large, clear, vacuole-like regions containing unsaturated triglycerides were located at the periphery of every tubule; these were apparent by 29 days of age and increased in severity with age

seminiferous tubule degeneration ( J:30560 )

• in 8-10 month old mice, tubules with reduced diameters were present with variable degrees of germ cell loss

• by 11-12 months, half the seminiferous tubules had degenerated

arrest of spermatogenesis ( J:30560 )

• late spermatids failed to align at luminal sides of tubules at late stage VII; later stages were retained in the seminiferous tubule epithelium and were phagocytosed by Sertoli cells

male infertility ( J:30560 )

• male mice that survive to adulthood are sterile