Phenotypes associated with this allele

• Allele Symbol: Msr1^tm1Csk
• Allele Name: targeted mutation 1, Chugai Pharmaceutical Co, Ltd
• Allele ID: MGI:1857874
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msr1^tm1Csk/Msr1^tm1Csk	B6.129X1-Msr1^tm1Csk	MGI:6108120
hm2	Msr1^tm1Csk/Msr1^tm1Csk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3053052
hm3	Msr1^tm1Csk/Msr1^tm1Csk	involves: 129X1/SvJ * ICR	MGI:2174971
cx4	Marco^tm1Ktry/Marco^tm1Ktry Msr1^tm1Csk/Msr1^tm1Csk	B6.129-Marco^tm1Ktry Msr1^tm1Csk	MGI:3714850
cx5	Apoe^tm1Unc/Apoe^tm1Unc Msr1^tm1Csk/Msr1^tm1Csk	either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)	MGI:2177115
cx6	Msr1^tm1Csk/Msr1^tm1Csk Scarf1^tm1Ishi/Scarf1^tm1Ishi	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J	MGI:3053051
cx7	Msr1^tm1Csk/Msr1^tm1Csk Tg(APPV717F)109Ili/?	involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR	MGI:2177120

Genotype
MGI:6108120

hm1

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: B6.129X1-Msr1^tm1Csk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-beta secretion ( J:251008 )

• in peritoneal macrophages stimulated with poly(I:C)

• however, TLR3 signaling is rescued by treatment with DOTAP

Genotype
MGI:3053052

hm2

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

immune system

abnormal macrophage physiology ( J:91911 )

• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

hematopoietic system

abnormal macrophage physiology ( J:91911 )

• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

Genotype
MGI:2174971

hm3

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: involves: 129X1/SvJ * ICR

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with herpes simplex virus, HSV-1

immune system

increased interleukin-12 secretion ( J:110433 )

• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:39079 )

• decreased survival after infection with herpes simplex virus, HSV-1

Genotype
MGI:3714850

cx4

• Allelic Composition: Marco^tm1Ktry/Marco^tm1Ktry; Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: B6.129-Marco^tm1Ktry Msr1^tm1Csk

immune system

abnormal spleen marginal zone morphology ( J:122271 )

• microarchitecture of the spleen marginal zone is altered

• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marco^tm1Ktry homozygotes

increased IgM level ( J:122271 )

• anti-polysaccharide IgM levels are increased

abnormal macrophage physiology ( J:122271 )

• macrophage adhesion or spreading is absent

increased susceptibility to bacterial infection ( J:122271 )

• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response

• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent

hematopoietic system

abnormal spleen marginal zone morphology ( J:122271 )

• microarchitecture of the spleen marginal zone is altered

• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marco^tm1Ktry homozygotes

increased IgM level ( J:122271 )

• anti-polysaccharide IgM levels are increased

abnormal macrophage physiology ( J:122271 )

• macrophage adhesion or spreading is absent

Genotype
MGI:2177115

cx5

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Msr1^tm1Csk/Msr1^tm1Csk
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

cardiovascular system

atherosclerotic lesions ( J:39079 )

• atherosclerotic plaques, but smaller than those seen in Apoe^tm1Unc mutant mice

homeostasis/metabolism

increased circulating cholesterol level ( J:39079 )

• increased plasma cholesterol concentrations

• plasma cholesterol concentrations greater than Apoe^tm1Unc mutant mice

Genotype
MGI:3053051

cx6

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk; Scarf1^tm1Ishi/Scarf1^tm1Ishi
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

immune system

abnormal macrophage physiology ( J:91911 )

• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

• this reduction is slightly greater than that of Msr1^tm1Kod homozygotes

hematopoietic system

abnormal macrophage physiology ( J:91911 )

• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

• this reduction is slightly greater than that of Msr1^tm1Kod homozygotes

Genotype
MGI:2177120

cx7

• Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk; Tg(APPV717F)109Ili/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR

nervous system

amyloid beta deposits ( J:58338 )

• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

neuron degeneration ( J:58338 )

• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )

• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)

homeostasis/metabolism

amyloid beta deposits ( J:58338 )

• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:58338