reproductive system
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• approximately 10-15% of males suffer from this
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• cryptorchism in some males, infertility in some females, and mounting difficulties due to limb abnormalities all lead to reduced fecundity
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• 25% of females are sterile
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limbs/digits/tail
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• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele
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immune system
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• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
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• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts
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• an absent spleen is characteristic of mice carrying the Dh allele
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• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls
• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls
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• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls
• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls
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• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls
• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls
• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls
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• Background Sensitivity: mice have increased levels of "naturally occurring thymocytotoxic IgM antibodies" (NTA) compared to NZB controls
• Background Sensitivity: 8 of 9 mice at 6 weeks of age have significant levels of NTAs compared to none in a similar sized group of age-matched NZB mice
• Background Sensitivity: at one year of age, all mice have a mean NTA log2titer of 4.5 compared to 60% of NZB controls with detectable amounts of NTA with a mean titer of 2.2
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• Background Sensitivity: 100% of animals by 9 months of age have detectable levels of anti-erythrocyte antibodies (i.e. positive Coombs' test)
• Background Sensitivity: while anti-erythrocyte antibodies are characteristic of the NZB strain, there are differences with this mouse strain in the immunoglobulin classes involved
• Background Sensitivity: one year old mice have a four-fold decrease in the serum level of anti-erythrocyte IgM with a corresponding increase in anti-erythrocyte IgG1
• Background Sensitivity: sheep red blood cells injected into 3 but not 9 month old mice have higher levels of agglutinating antibody coating the cells than in NZB controls t
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• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-polyIpolyC antibodies, which is similar to NZB controls
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• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-single stranded DNA antibodies, which is similar to NZB controls
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• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls
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• thymocytes isolated from these mice at 20 weeks of age are better able to suppress graft versus host disease (GVHD )than controls in an induced form of GVHD caused by transfer with wild-type NZB splenocytes into an irradiated host
• similar suppression of GVHD as controls is observed when thymocytes are isolated from 4 week old mice
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renal/urinary system
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• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls
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neoplasm
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• Background Sensitivity: lymphomas, which occur in 11% of NZB mice by one year of age, are not observed in these mice
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endocrine/exocrine glands
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• approximately 10-15% of males suffer from this
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skeleton
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• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele
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hematopoietic system
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• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
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• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts
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• an absent spleen is characteristic of mice carrying the Dh allele
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• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls
• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls
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• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls
• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls
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• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls
• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls
• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls
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cellular
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• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
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• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts
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