All Phenotypes plt MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	plt/plt	B6.DDD-plt	MGI:4430603
hm2	plt/plt	C.DDD-plt	MGI:3762343
hm3	plt/plt	either: B6.DDD-plt or C.DDD-plt	MGI:4437582
hm4	plt/plt	involves: DDD/1	MGI:2660691

Allelic Composition	plt/plt
Genetic Background	B6.DDD-plt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:93960 )

N	• no single positive T cell abnormalities other than the migration defect from cortex to medulla of the thymus

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

hematopoietic system

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

cellular

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

Allelic Composition	plt/plt
Genetic Background	C.DDD-plt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased single-positive T cell number ( J:119345 )

• the amount of CD4+ or CD8+ T cells are decreased in lymph nodes compared to in wild-type mice

• however, remaining single positive cells undergo normal activation and proliferation alloresponses

abnormal T cell activation ( J:119345 )

• mice exhibit impaired T cell activation following receipt of islet allografts compared to wild-type mice

• however, T cell alloresponses are normal

increased length of allograft survival ( J:119345 )

• islet allografts function for over 120 days compared to in wild-type mice in which rejection occurs at 14 days

• unlike in wild-type mice, cardiac allograft survival time is doubled after the spleen is removed

• however, cardiac allografts are rejected at the same tempo as in wild-type mice

hematopoietic system

decreased single-positive T cell number ( J:119345 )

• the amount of CD4+ or CD8+ T cells are decreased in lymph nodes compared to in wild-type mice

• however, remaining single positive cells undergo normal activation and proliferation alloresponses

abnormal T cell activation ( J:119345 )

• mice exhibit impaired T cell activation following receipt of islet allografts compared to wild-type mice

• however, T cell alloresponses are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

abnormal gland morphology ( J:110910 )

• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice

abnormal parotid gland morphology ( J:110910 )

• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice

abnormal submandibular gland morphology ( J:110910 )

• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice

abnormal lacrimal gland morphology ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

immune system

abnormal leukocyte migration ( J:110910 )

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

increased susceptibility to autoimmune disorder ( J:110910 )

• mice exhibit autoimmune exocrinopathy unlike wild-type mice

increased inflammatory response ( J:110910 )

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:110910 )

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

digestive/alimentary system

abnormal parotid gland morphology ( J:110910 )

• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice

abnormal submandibular gland morphology ( J:110910 )

• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

vision/eye

abnormal lacrimal gland morphology ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

cellular

abnormal leukocyte migration ( J:110910 )

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:110910 )

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:110910

Allelic Composition	plt/plt
Genetic Background	involves: DDD/1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte cell number ( J:47819 )

decreased T cell number ( J:47819 )

• the total number of T cells in lymph nodes is smaller than in BALB/c mice

decreased single-positive T cell number ( J:15290 )

• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice

increased T cell number ( J:47819 )

• the number of T cells in the blood and spleen is increased compared to in wild-type mice

increased memory T cell number ( J:47460 )

• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice

abnormal immune system organ morphology ( J:47819 )

abnormal spleen red pulp morphology ( J:47460 )

• unlike in wild-type spleens, T cells are found within the red pulp

abnormal spleen white pulp morphology ( J:47460 )

• unlike in wild-type spleens, few T cells are found within the white pulp

small Peyer's patches ( J:47460 )

• most Peyer's patches are smaller than in wild-type mice

abnormal lymph node T cell domain morphology ( J:47460 , J:47819 )

• T cells are hardly observed in T cell zones but are observed in B cell zones (J:47460)

• low density of T cells in subcortical area (J:47819)

lymph node hypoplasia ( J:15290 , J:47460 )

• the number of lymph node cells is reduced by 10 and 6 times in males and females, respectively, than in CBA and B6 mice (J:15290)

• T cell cellularity within the peripheral lymph nodes is decreased (J:47460)

abnormal peripheral lymph node morphology ( J:47819 )

• the amount of T cells in the subcortical area is extremely low

abnormal immune system physiology ( J:47819 )

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)

hematopoietic system

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)

abnormal leukocyte cell number ( J:47819 )

decreased T cell number ( J:47819 )

• the total number of T cells in lymph nodes is smaller than in BALB/c mice

decreased single-positive T cell number ( J:15290 )

• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice

increased T cell number ( J:47819 )

• the number of T cells in the blood and spleen is increased compared to in wild-type mice

increased memory T cell number ( J:47460 )

• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice

abnormal spleen red pulp morphology ( J:47460 )

• unlike in wild-type spleens, T cells are found within the red pulp

abnormal spleen white pulp morphology ( J:47460 )

• unlike in wild-type spleens, few T cells are found within the white pulp

cellular

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)

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