Phenotypes associated with this allele

• Allele Symbol: Hsp90ab1^{Gt(pGT1.8geo)1Pgr}
• Allele Name: gene trap 1, Peter Gruss
• Allele ID: MGI:1857893
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsp90ab1^Gt(pGT1.8geo)1Pgr/Hsp90ab1^Gt(pGT1.8geo)1Pgr	either: (involves: 129 * C57BL/6) or (involves: 129 * NMRI)	MGI:2170356

Genotype
MGI:2170356

hm1

• Allelic Composition: Hsp90ab1^{Gt(pGT1.8geo)1Pgr}/Hsp90ab1^{Gt(pGT1.8geo)1Pgr}
• Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * NMRI)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:58075 )

• normal development to E9-E9.5

• no heartbeat at E10.5 but no morphological abnormalities

• development retarded

embryo

abnormal placenta vasculature ( J:58075 )

• allantoic blood vessels do not expand after penetrating the chorionic plate

embryo tissue necrosis ( J:58075 )

• necrotic cells in tissues at E10.5

abnormal placenta labyrinth morphology ( J:58075 )

• labyrinthine trophoblast fails to form

abnormal trophoblast layer morphology ( J:58075 )

• trophoblast continues to proliferate but fails to associate normally with blood vessels

cardiovascular system

abnormal placenta vasculature ( J:58075 )

• allantoic blood vessels do not expand after penetrating the chorionic plate

absent heartbeat ( J:58075 )

• heart not beating at E10.5