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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmp2tm1Brd
targeted mutation 1, Allan Bradley
MGI:1857894
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmp2tm1Brd/Bmp2tm1Brd involves: 129S7/SvEvBrd * C57BL/6 MGI:2658703
ht2
 		Bmp2tm1Brd/Bmp2tm1Mis involves: 129S7/SvEvBrd * C57BL/6J MGI:3822028
ht3
 		Bmp2tm1Brd/Bmp2tm1.1Mis involves: 129S/SvEv * C57BL/6J MGI:3822029
cn4
 		Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4430834
cn5
 		Bmp2tm1Brd/Bmp2tm1.1Mis
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4430833
cx6
 		Bmp2tm1Brd/Bmp2+
Tbx1tm1Pa/Tbx1+ 		involves: 129/Sv * C57BL/6 MGI:3611300
cx7
 		Bmp2tm1Brd/Bmp2+
Bmp7tm1Kry/Bmp7+ 		Not Specified MGI:3047104


Genotype
MGI:2658703
hm1
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:36213 )
• homozygous mutant embryos die between E7-E10.5

embryo
incomplete embryo turning ( J:36213 )
• at E9.5, 9 of 9 homozygotes fail to complete axial turning
decreased embryo size ( J:36213 )
• at E9.5, homozygotes are smaller than wild-type embryos
open neural tube ( J:36213 )
• at E9.5, homozygotes display an open neural tube with blood cells in the headfold (probably secondary consequences of heart defect)
abnormal chorion morphology ( J:36213 )
• at E8.5 and E9.5, ~70% of homozygotes retain an open proamniotic canal, leading to chorion malformation
abnormal proamniotic cavity morphology ( J:36213 )
• at E8.5 and E9.5, ~70% of homozygotes retain an open proamniotic canal
• by E10.5, 2 of 2 homozygotes exhibit an open proamniotic canal
delayed allantois development ( J:36213 )
• at E8.5 and E9.5, all homozygotes display delayed allantois development
• in some cases, the mutant allantois fails to reach the ectoplacental cone

cardiovascular system
abnormal heart development ( J:36213 )
• at E8.5 and E9.5, 2 of 12 homozygotes display no signs of heart development, despite an apparently normal amnion/chorion formation
delayed heart development ( J:36213 )
• at E8.5, homozygotes display delayed cardiac development relative to wild-type embryos
• at E9.5, homozygotes still exhibit a single heart tube whereas wild-type embryos show a more differentiated heart consisting of a well-formed AV canal
abnormal heart position or orientation ( J:36213 )
• at E8.5 and E9.5, >75% of homozygotes exhibit a disorganized heart that is abnormally positioned in the exocoelomic cavity insted of the putative amniotic cavity

nervous system
open neural tube ( J:36213 )
• at E9.5, homozygotes display an open neural tube with blood cells in the headfold (probably secondary consequences of heart defect)

growth/size/body
decreased embryo size ( J:36213 )
• at E9.5, homozygotes are smaller than wild-type embryos




Genotype
MGI:3822028
ht2
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1Mis
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Mis mutation (1 available); any Bmp2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:141834 )
• in crosses of heterozygous mice the proportion of trans-heterozygous pups is underrepresented; no specific time of lethality was provided
• underrepresentation is more severe when the mother is heterozygous for the null allele

growth/size/body
decreased body weight ( J:141834 )
• seen in surviving pups at 38 days of age
herniated abdominal wall ( J:141834 )
• some embryos develop a body wall hernia in the ventral abdominal region
• frequency of hernias is highest when the mother is heterozygous for the null allele

nervous system
incomplete rostral neuropore closure ( J:141834 )
• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother
exencephaly ( J:141834 )
• develops by midgestation in embryos with cephalic neural tube closure defects

limbs/digits/tail

reproductive system
long gestation period ( J:141834 )
• slightly increased compared to females heterozygous for the null allele only
decreased litter size ( J:141834 )
• dramatically reduced litter size compared to wild-type females

embryo
incomplete rostral neuropore closure ( J:141834 )
• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother




Genotype
MGI:3822029
ht3
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:141834 )
N
• the expected proportion of trans-heterozygous pups are detected, unlike for mice trans-heterozygous for Bmp2tm1Brd and Bmp2tm1Mis




Genotype
MGI:4430834
cn4
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:156945 )
• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls




Genotype
MGI:4430833
cn5
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:156945 )
N
• no obvious abnormalities in cochlea morphology is observed




Genotype
MGI:3611300
cx6
Allelic
Composition		 Bmp2tm1Brd/Bmp2+
Tbx1tm1Pa/Tbx1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Tbx1tm1Pa mutation (2 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal pharyngeal arch artery morphology ( J:80764 )
• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice

craniofacial
abnormal pharyngeal arch artery morphology ( J:80764 )
• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice

embryo
abnormal pharyngeal arch artery morphology ( J:80764 )
• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice




Genotype
MGI:3047104
cx7
Allelic
Composition		 Bmp2tm1Brd/Bmp2+
Bmp7tm1Kry/Bmp7+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Bmp7tm1Kry mutation (1 available); any Bmp7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:48538 )
N
• doubly heterozygous pups have a normal skeleton and display no rib cage abnormalities or limb defects




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory